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Structure determination and ligand interactions of the PDZ2b domain of PTP-Bas (hPTP1E): splicing-induced modulation of ligand specificity

Kachel, Norman and Erdmann, Kai Sven and Kremer, Werner and Wolff, Peter and Gronwald, Wolfram and Heumann, Rolf and Kalbitzer, Hans Robert (2003) Structure determination and ligand interactions of the PDZ2b domain of PTP-Bas (hPTP1E): splicing-induced modulation of ligand specificity. Journal of molecular biology 334 (1), pp. 143-155.

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Abstract

Two versions of the PDZ2 domain of the protein tyrosine phosphatase PTP-Bas/human PTP-BL are generated by alternative splicing. The domains differ by the insertion of five amino acid residues and their affinity to the tumour suppressor protein APC. Whereas PDZ2a is able to bind APC in the nanomolar range, PDZ2b shows no apparent interaction with APC. Here the solution structure of the splicing ...

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Item Type:Article
Date:2003
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
14596806PubMed ID
Classification:
NotationType
Adenomatous Polyposis Coli Protein/metabolismMESH
Alternative SplicingMESH
Amino Acid SequenceMESH
Binding SitesMESH
HumansMESH
LigandsMESH
Models, MolecularMESH
Molecular Sequence DataMESH
Nuclear Magnetic Resonance, BiomolecularMESH
Peptide Fragments/metabolismMESH
Phosphatidylinositol 4,5-Diphosphate/metabolismMESH
Phosphatidylinositol Phosphates/metabolismMESH
Protein Structure, TertiaryMESH
Protein Tyrosine Phosphatase, Non-Receptor Type 13MESH
Protein Tyrosine Phosphatases/metabolismMESH
Sequence AlignmentMESH
Two-Hybrid System TechniquesMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:16 Sep 2010 09:13
Last Modified:16 Sep 2010 09:13
Item ID:16601
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