Ellenrieder, Anja-Daniela and Kremer, Werner and Kattenbeck, Bernhard and Hantschel, Oliver and Horn, Gudrun and Kalbitzer, Hans Robert and Modrow, Susanne (2004) The central domain of the matrix protein of HIV-1: influence on protein structure and virus infectivity. Biological chemistry 385 (3-4), pp. 303-313.
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The central region of the matrix protein p17 of HIV-1 is known to be essential during virus assembly. We substituted alanines for amino acid triplets in this region of p17 (amino acid residues 47 to 55: NPG LLE TSE). Introduction of the respective mutations into the gag-coding sequence of HI-proviruses and subsequent transfection into Cos-7 cells led to particle production and release. Exchange ...
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|Institutions:||Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer|
|Subjects:||500 Science > 570 Life sciences|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||16 Sep 2010 09:15|
|Last Modified:||16 Sep 2010 09:15|