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Species-specific differences in the intermediate states of human and Syrian hamster prion protein detected by high pressure NMR spectroscopy

Kremer, Werner and Kachel, Norman and Kuwata, Kazuo and Akasaka, Kazuyuki and Kalbitzer, Hans Robert (2007) Species-specific differences in the intermediate states of human and Syrian hamster prion protein detected by high pressure NMR spectroscopy. The Journal of biological chemistry 282 (31), pp. 22689-22698.

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Abstract

Human (huPrP) and Syrian hamster (ShaPrP) prion proteins have barriers for mutual infectivity, although they fold into almost an identical structure. The pressure responses of huPrP and ShaPrP characterized by high pressure NMR spectroscopy show differences in their excited states, as monitored by pressure-induced chemical shifts and intensity changes of individual residues in the (15)N/(1)H HSQC ...

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Item Type:Article
Date:2007
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
17519231PubMed ID
10.1074/jbc.M701884200DOI
Classification:
NotationType
Amino Acid SequenceMESH
AnimalsMESH
CricetinaeMESH
HumansMESH
Magnetic Resonance Spectroscopy/methodsMESH
MesocricetusMESH
Molecular ConformationMESH
Molecular Sequence DataMESH
Prions/metabolismMESH
Protein ConformationMESH
Protein FoldingMESH
Recombinant Proteins/chemistryMESH
Sequence Homology, Amino AcidMESH
Species SpecificityMESH
ThermodynamicsMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:17 Sep 2010 07:28
Last Modified:17 Sep 2010 07:28
Item ID:16656
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