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Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains

Brügger, Britta and Krautkrämer, Ellen and Tibroni, Nadine and Munte, Claudia E. and Rauch, Susanne and Leibrecht, Iris and Glass, Bärbel and Breuer, Sebastian and Geyer, Matthias and Kräusslich, Hans-Georg and Kalbitzer, Hans Robert and Wieland, Felix T. and Fackler, Oliver T. (2007) Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovirology 4, p. 70.

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Abstract

BACKGROUND: The Nef protein of Human Immunodeficiency Viruses optimizes viral spread in the infected host by manipulating cellular transport and signal transduction machineries. Nef also boosts the infectivity of HIV particles by an unknown mechanism. Recent studies suggested a correlation between the association of Nef with lipid raft microdomains and its positive effects on virion infectivity. ...

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Item Type:Article
Date:2007
Additional information (public):Online-Ressource
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
16777597PubMed ID
10.1186/1742-4690-4-70DOI
Classification:
NotationType
Antigens, CD4/metabolismMESH
Cells, CulturedMESH
Cholesterol/metabolismMESH
Gene Products, gag/metabolismMESH
HIV-1/pathogenicityMESH
HumansMESH
Membrane Microdomains/virologyMESH
Phosphatidylcholines/metabolismMESH
Sphingomyelins/metabolismMESH
T-Lymphocytes/virologyMESH
Virion/pathogenicityMESH
Virus Replication/physiologyMESH
nef Gene Products, Human Immunodeficiency Virus/metabolismMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:17 Sep 2010 07:20
Last Modified:17 Sep 2010 07:20
Item ID:16658
Owner Only: item control page
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