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Zusammenfassung
In vivo skin penetration studies of the Chamomile flavones apigenin, luteolin and apigenin 7-O-beta -glucoside were carried out with nine healthy, female volunteers. During seven h, the decline of flavonoid concn. in a satd. aq. alc. soln. filled in glass application chambers were repeatedly measured by spectrophotometry at fixed time periods. The max. fluxes were calcd. From the graph of the ...
Zusammenfassung
In vivo skin penetration studies of the Chamomile flavones apigenin, luteolin and apigenin 7-O-beta -glucoside were carried out with nine healthy, female volunteers. During seven h, the decline of flavonoid concn. in a satd. aq. alc. soln. filled in glass application chambers were repeatedly measured by spectrophotometry at fixed time periods. The max. fluxes were calcd. From the graph of the max. flux values as a function of time, it was concluded that the flavonoids are not only adsorbed at the skin surface, but also penetrate into deeper skin layers. This is important for their topical use as antiphlogistic agents.