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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Phytochemistry | ||||
| Verlag: | Elsevier | ||||
| Band: | 54 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 5 | ||||
| Seitenbereich: | S. 531-537 | ||||
| Datum: | 2000 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 133:249671 11-1 Plant Biochemistry 1258-84-0 (Pristimerin); 34157-83-0 (Celastrol); 39903-21-4 Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (antibacterial terpenoids from Crossopetalum gaumeri); 295323-25-0P; 295323-26-1P; 342775-67-1P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (antibacterial terpenoids from Crossopetalum gaumeri); 17291-05-3 (Ourateacatechin) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (cytotoxic agents from Crossopetalum gaumeri); 22333-73-9 Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (cytotoxic cardenolides from Crossopetalum gaumeri); 295323-22-7P; 295323-23-8P; 295323-24-9P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (cytotoxic cardenolides from Crossopetalum gaumeri) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Antibacterial agents (antibacterial terpenoids from Crossopetalum gaumeri) Diterpenes Triterpenes Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) Steroids Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (ca cytotoxic cardenolides from Crossopetalum gaumeri) New natural products (cardenolides and terpenoids from Crossopetalum gaumeri) Crossopetalum gaumeri (cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri) Cytotoxic agents (cytotoxic cardenolides from Crossopetalum gaumeri) Molecular structure (of cardenolides and terpenoids from Crossopetalum gaumeri) cardenolide Crossopetalum cytotoxic agent terpenoid Crossopetalum antibacterial agent | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Nein | ||||
| Dokumenten-ID: | 17182 |
Zusammenfassung
From the methanol ext. of the roots of Crossopetalum gaumeri, four new highly cytotoxic cardenolides, securigenin-3beta -O-beta -6-deoxyguloside, 19-hydroxy-sarmentogenin-3beta -O-beta -6-deoxyguloside, sarmentogenin-3beta -O-[alpha -allosyl-(1-> 4)-beta -6-deoxyalloside], and securigenin-3beta -O-[alpha -allosyl-(1->4)-beta -6-deoxyalloside] were isolated. The dichloromethane ext. afforded the ...
Zusammenfassung
From the methanol ext. of the roots of Crossopetalum gaumeri, four new highly cytotoxic cardenolides, securigenin-3beta -O-beta -6-deoxyguloside, 19-hydroxy-sarmentogenin-3beta -O-beta -6-deoxyguloside, sarmentogenin-3beta -O-[alpha -allosyl-(1-> 4)-beta -6-deoxyalloside], and securigenin-3beta -O-[alpha -allosyl-(1->4)-beta -6-deoxyalloside] were isolated. The dichloromethane ext. afforded the new diterpene 3,15-dihydroxy-18-norabieta-3,8,11,13-tetraene as well as the new triterpene 2,3,7-trihydroxy-6-oxo-1,3,5(10),7-tetraene-24-nor-friedelane-29-oic acid Me ester. The new terpenoids lack cytotoxicity and the antibacterial activity is moderate to low.
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