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Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri

Ankli, A. and Heilmann, Jörg and Heinrich, M. and Sticher, O. (2000) Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri. Phytochemistry 54 (5), pp. 531-537.

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Abstract

From the methanol ext. of the roots of Crossopetalum gaumeri, four new highly cytotoxic cardenolides, securigenin-3beta -O-beta -6-deoxyguloside, 19-hydroxy-sarmentogenin-3beta -O-beta -6-deoxyguloside, sarmentogenin-3beta -O-[alpha -allosyl-(1-> 4)-beta -6-deoxyalloside], and securigenin-3beta -O-[alpha -allosyl-(1->4)-beta -6-deoxyalloside] were isolated. The dichloromethane ext. afforded the new diterpene 3,15-dihydroxy-18-norabieta-3,8,11,13-tetraene as well as the new triterpene 2,3,7-trihydroxy-6-oxo-1,3,5(10),7-tetraene-24-nor-friedelane-29-oic acid Me ester. The new terpenoids lack cytotoxicity and the antibacterial activity is moderate to low.

Item Type:

Article

Additional information (public):

CAN 133:249671 11-1 Plant Biochemistry 1258-84-0 (Pristimerin); 34157-83-0 (Celastrol); 39903-21-4 Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (antibacterial terpenoids from Crossopetalum gaumeri); 295323-25-0P; 295323-26-1P; 342775-67-1P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (antibacterial terpenoids from Crossopetalum gaumeri); 17291-05-3 (Ourateacatechin) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (cytotoxic agents from Crossopetalum gaumeri); 22333-73-9 Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (cytotoxic cardenolides from Crossopetalum gaumeri); 295323-22-7P; 295323-23-8P; 295323-24-9P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (cytotoxic cardenolides from Crossopetalum gaumeri)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)

Identification Number:

Value	Type
2000:531441	Other

Keywords:

Antibacterial agents (antibacterial terpenoids from Crossopetalum gaumeri) Diterpenes Triterpenes Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) Steroids Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (ca cytotoxic cardenolides from Crossopetalum gaumeri) New natural products (cardenolides and terpenoids from Crossopetalum gaumeri) Crossopetalum gaumeri (cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri) Cytotoxic agents (cytotoxic cardenolides from Crossopetalum gaumeri) Molecular structure (of cardenolides and terpenoids from Crossopetalum gaumeri) cardenolide Crossopetalum cytotoxic agent terpenoid Crossopetalum antibacterial agent

Subjects:

500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Owner:

Prof. Dr. Joerg Heilmann

Deposited On:

15 Oct 2010 12:27

Last Modified: