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Antiprotozoal activity and cytotoxicity of novel 1,7-dioxadispiro[5.1.5.2]pentadeca-9,12-dien-11-one derivatives from Amomum aculeatum

Heilmann, Jörg and Mayr, Stefan and Brun, Reto and Rali, Topul and Sticher, Otto (2000) Antiprotozoal activity and cytotoxicity of novel 1,7-dioxadispiro[5.1.5.2]pentadeca-9,12-dien-11-one derivatives from Amomum aculeatum. Helvetica Chimica Acta 83 (11), pp. 2939-2945.

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Abstract

Cytotoxicity against the KB cancer cell line as a lead bioactivity-guided fractionation of the petroleum ether ext. of rhizomes of Amomum aculeatum RoxB. led to the isolation of three novel dioxadispiro[5.1.5.2]-pentadeca-9,12-dien-11-one derivs. The structures of aculeatin A, aculeatin B, and aculeatin C were established as rel-(2R,4R,6S)- and ...

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Item Type:Article
Date:2000
Additional information (public):CAN 134:172732 1-5 Pharmacology 326794-05-2P (Aculeatin A); 326794-06-3P (Aculeatin B); 326794-07-4P (Aculeatin C) Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (antiprotozoal activity and cytotoxicity of novel dioxadispiro pentadeca dienone derivs. from Amomum aculeatum)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2000:882195Other
Keywords:Molecular structure (Aculeatin A (dioxa dispiropentadecadienone) Molecular structure (Aculeatin B (dioxa dispiropentadecadienone) Molecular structure (Aculeatin C (dioxa dispiropentadecadienone) Amomum aculeatum Antitumor agents New natural products Protozoacides (antiprotozoal activity and cytotoxicity of novel dioxadispiro pentadeca dienone derivs. from Amomum aculeatum) antiprotozoal cytotoxicity dioxadispiropentadecadien deriv isolation Amomum structure activity antiprotozoal cytotoxicity aculeatin
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Prof. Dr. Joerg Heilmann
Deposited On:15 Oct 2010 10:30
Last Modified:15 Oct 2010 10:30
Item ID:17184
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