Quadri-Spinelli, T. and Heilmann, Jörg and Rali, T. and Sticher, O. (2000) Bioactive coumarin derivatives from the fern Cyclosorus interruptus. Planta medica 66 (8), pp. 728-733.
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Three new coumarin derivatives, compounds 1-3, three new furanocoumarins, compounds 4-6, and a novel dioxocane derivative, compound 7, were isolated from the fern Cyclosorus interruptus (Willd.) H. Ito. Based on spectrometric and spectroscopic analysis (FAB or El mass spectrometry as well as 1D and 2D NMR experiments) their structures were characterised as 5,7-dihydroxy-6-methyl-4-phenyl-8-(3-phenylpropionyl)-1-benzopyran-2-one (1), 5,7-dihydroxy-6-methyl-4-phenyl-8-(3-phenyl-trans-acryloyl)-1- benzopyran-2-one (2), 5,7-dihydroxy-8-(2-hydroxy-3-phenylpropionyl)-6-methyl-4-phenyl-1- benzopyran-2-one (3), 8-benzyl-5,8-dihydroxy-6-methyl-4-phenylfuro[2,3-h]-1-benzopyran-2,9- dione (4), 8-benzyl-5,8 beta,9 beta-trihydroxy-6-methyl-4-phenyl-8,9-dihydro- furo[2,3-h]-1-benzopyran-2-one (5), 8-benzyl-5,8 beta,9 alpha-trihydroxy-6-methyl-4-phenyl-8,9-dihydro- furo[2,3-h]-1-benzopyran-2-one (6) and 5,11-dihydroxy-6-methyl-4-phenyl-11-(1-phenylmethyl)-7,10-dioxocane [5,6-h]-1-benzopyran-2,12-dione (7). For these compounds we propose the trivial names interruptins A-F. Compounds 1, 5/6 and 7 showed antibacterial activity while compounds 1 and 2 were cytotoxic to a KB cell line.
|Additional information (public):||Germany: Germany, Federal Republic of 91-64-5 (coumarin)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)|
|Keywords:||Anti-Infective Agents: CH, chemistry *Anti-Infective Agents: IP, isolation & purification Anti-Infective Agents: PD, pharmacology *Coumarins: CH, chemistry Coumarins: PD, pharmacology Microbial Sensitivity Tests Plant Extracts: CH, chemistry *Plant Extracts: IP, isolation & purification Plant Extracts: PD, pharmacology *Plants: CH, chemistry Spectrum Analysis 0 (Anti-Infective Agents) 0 (Coumarins) 0 (Plant Extracts)|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||No|
|Owner:||Prof. Dr. Joerg Heilmann|
|Deposited On:||18 Oct 2010 12:31|
|Last Modified:||18 Oct 2010 12:32|
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