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Zusammenfassung
Five new prenylated tricyclic and three new bicyclic acylphloroglucinol derivs. have been isolated by bioactivity-guided fractionation of the petroleum ether ext. of the dried aerial parts of Hypericum papuanum. The tricyclic compds. (1-5) were named papuaforins A-E. The bicyclic compds. were isolated together with their corresponding tautomers and were named hyperguinones A and B (6/6a, 7/7a) ...
Zusammenfassung
Five new prenylated tricyclic and three new bicyclic acylphloroglucinol derivs. have been isolated by bioactivity-guided fractionation of the petroleum ether ext. of the dried aerial parts of Hypericum papuanum. The tricyclic compds. (1-5) were named papuaforins A-E. The bicyclic compds. were isolated together with their corresponding tautomers and were named hyperguinones A and B (6/6a, 7/7a) and hyperpapuanone (8/8a), resp. Their structures were elucidated on the basis of extensive 1D and 2D NMR expts., as well as mass spectrometry. Furthermore, the cytotoxicity toward KB nasopharyngeal carcinoma cells and the antibacterial activity of the isolated compds. were detd.