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Novel antileukemic sterol glycosides from Ajuga salicifolia

Akbay, Pinar and Gertsch, Juerg and Cahs, Ihsan and Heilmann, Jörg and Zerbe, Oliver and Sticher, Otto (2002) Novel antileukemic sterol glycosides from Ajuga salicifolia. Helvetica chimica acta 85 (7), pp. 1930-1942.

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Abstract

Two novel and three new sterol glycosides were isolated from the MeOH ext. of the aerial parts of Ajuga salicifolia (L.) Schreber. The structures of the compds. were elucidated as (3R,16S,17S,20R,22S,23S,24S,25S)-16,23:16,27:22,25-triepoxy-3-(beta -D-glucopyranosyloxy)coprostigmast-7-en-17-ol (I), (3R,16S,17S,20R,22S,23S,24S,25S)-16,23:16,27:22,25-triepoxy-3-{[beta -D-glucopyranosyl-(1->2)-beta ...

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Item Type:Article
Date:2002
Additional information (public):CAN 138:22094 11-1 Plant Biochemistry 478015-46-2P (Ajugasalicioside A); 478015-47-3P (Ajugasalicioside B); 478015-48-4P (Ajugasalicioside C); 478015-49-5P (Ajugasalicioside D); 478015-50-8P (Ajugasalicioside E) Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (cytotoxicity, isolation, and structure of antileukemic sterol glycosides from Ajuga salicifolia)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2002:627833Other
Keywords:Cyclins Role: BSU (Biological study, unclassified), BIOL (Biological study) (D1 ajugasalicioside A inhibition of Jurkat T cell proliferation, up-regulation of mRNA levels of cyclin D1, and down-regulation of those of NF-kB subunit p65) Animal cell line (JURKAT ajugasalicioside A induction of cell-cell contact, inhibition of cell proliferation, and regulation of mRNA levels in) Transcription factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (NF-kB (nuclear factor of k light chain gene enhancer in B-cells) ajugasalicioside A inhibition of Jurkat T cell proliferation, up-regulation of mRNA levels of cyclin D1, and down-regulation of those of NF-kB subunit p65) Cell proliferation (ajugasalicioside A inhibition of Jurkat T cell proliferation) mRNA Role: BSU (Biological study, unclassified), BIOL (Biological study) (ajugasalicioside A inhibition of Jurkat T cell proliferation, up-regulation of mRNA levels of cyclin D1, and down-regulation of those of NF-kB subunit p65) Mononuclear cell (ajugasalicioside C cytotoxicity to human cells) New natural products (ajugasaliciosides A-E (sterol glycosides) Antitumor agents (antileukemic sterol glycosides named ajugasaliciosides from Ajuga salicifolia as) Human (cytotoxicity of ajugasaliciosides to HeLa cells, Jurkat T cells, and human peripheral mononuclear blood cells) Cytotoxicity (of ajugasalicioside C to human peripheral mononuclear blood cells) Molecular structure (of ajugasaliciosides A-E (sterol glycosides) Glycosides Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (steroidal cytotoxicity, isolation, and structure of antileukemic sterol glycosides from Ajuga salicifolia) antileukemic sterol glycoside Ajuga ajugasalicioside structure
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Prof. Dr. Joerg Heilmann
Deposited On:18 Oct 2010 10:59
Last Modified:18 Oct 2010 10:59
Item ID:17201
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