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Novel antileukemic sterol glycosides from Ajuga salicifolia

Akbay, Pinar und Gertsch, Juerg und Cahs, Ihsan und Heilmann, Jörg und Zerbe, Oliver und Sticher, Otto (2002) Novel antileukemic sterol glycosides from Ajuga salicifolia. Helvetica chimica acta 85 (7), S. 1930-1942.

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Zusammenfassung

Two novel and three new sterol glycosides were isolated from the MeOH ext. of the aerial parts of Ajuga salicifolia (L.) Schreber. The structures of the compds. were elucidated as (3R,16S,17S,20R,22S,23S,24S,25S)-16,23:16,27:22,25-triepoxy-3-(beta -D-glucopyranosyloxy)coprostigmast-7-en-17-ol (I), (3R,16S,17S,20R,22S,23S,24S,25S)-16,23:16,27:22,25-triepoxy-3-{[beta -D-glucopyranosyl-(1->2)-beta ...

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Dokumentenart:Artikel
Datum:2002
Zusätzliche Informationen (Öffentlich):CAN 138:22094 11-1 Plant Biochemistry 478015-46-2P (Ajugasalicioside A); 478015-47-3P (Ajugasalicioside B); 478015-48-4P (Ajugasalicioside C); 478015-49-5P (Ajugasalicioside D); 478015-50-8P (Ajugasalicioside E) Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (cytotoxicity, isolation, and structure of antileukemic sterol glycosides from Ajuga salicifolia)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2002:627833Andere
Stichwörter / Keywords:Cyclins Role: BSU (Biological study, unclassified), BIOL (Biological study) (D1 ajugasalicioside A inhibition of Jurkat T cell proliferation, up-regulation of mRNA levels of cyclin D1, and down-regulation of those of NF-kB subunit p65) Animal cell line (JURKAT ajugasalicioside A induction of cell-cell contact, inhibition of cell proliferation, and regulation of mRNA levels in) Transcription factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (NF-kB (nuclear factor of k light chain gene enhancer in B-cells) ajugasalicioside A inhibition of Jurkat T cell proliferation, up-regulation of mRNA levels of cyclin D1, and down-regulation of those of NF-kB subunit p65) Cell proliferation (ajugasalicioside A inhibition of Jurkat T cell proliferation) mRNA Role: BSU (Biological study, unclassified), BIOL (Biological study) (ajugasalicioside A inhibition of Jurkat T cell proliferation, up-regulation of mRNA levels of cyclin D1, and down-regulation of those of NF-kB subunit p65) Mononuclear cell (ajugasalicioside C cytotoxicity to human cells) New natural products (ajugasaliciosides A-E (sterol glycosides) Antitumor agents (antileukemic sterol glycosides named ajugasaliciosides from Ajuga salicifolia as) Human (cytotoxicity of ajugasaliciosides to HeLa cells, Jurkat T cells, and human peripheral mononuclear blood cells) Cytotoxicity (of ajugasalicioside C to human peripheral mononuclear blood cells) Molecular structure (of ajugasaliciosides A-E (sterol glycosides) Glycosides Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (steroidal cytotoxicity, isolation, and structure of antileukemic sterol glycosides from Ajuga salicifolia) antileukemic sterol glycoside Ajuga ajugasalicioside structure
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Nein
Eingebracht am:18 Okt 2010 10:59
Zuletzt geändert:18 Okt 2010 10:59
Dokumenten-ID:17201
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