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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Planta medica | ||||
| Verlag: | Thieme | ||||
| Band: | 69 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 5 | ||||
| Seitenbereich: | S. 420-424 | ||||
| Datum: | 2003 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 139:377900 11-1 Plant Biochemistry 623943-73-7P (Piscatorin) Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum); 17951-19-8P (Justicidin B) Role: BSU (Biological study, unclassified), PUR (Purification or recovery), BIOL (Biological study), PREP (Preparation) (antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Antibiotics Fungicides Phyllanthus piscatorum Protozoacides (antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum) Toxins Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (cytotoxins antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum) Molecular structure (of piscatorin (arylnaphthalide lignan) New natural products (piscatorin (arylnaphthalide lignan) Pesticides (piscicides antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum) Phyllanthus justicidin B piscatorin fungicide protozoacide cytotoxin piscicide | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Nein | ||||
| Dokumenten-ID: | 17213 |
Zusammenfassung
Using activity against Candida albicans as a lead, the bioactivity-guided fractionation of the CH2Cl2 ext. of P. piscatorum led to the isolation of the arylnaphthalide lignan justicidin B (I), which was found to be present in high amts., and a new C-11 hydroxylated deriv. that we named piscatorin (II). We provide evidence that I is the main active principle of P. piscatorum, showing the same ...
Zusammenfassung
Using activity against Candida albicans as a lead, the bioactivity-guided fractionation of the CH2Cl2 ext. of P. piscatorum led to the isolation of the arylnaphthalide lignan justicidin B (I), which was found to be present in high amts., and a new C-11 hydroxylated deriv. that we named piscatorin (II). We provide evidence that I is the main active principle of P. piscatorum, showing the same biol. effects that were found for the raw exts. I inhibited the growth of the pathogenic fungi Aspergillus fumigatus, Aspergillus flavus, and Candida albicans, but was not effective against Cryptococcus neoformans and Blastoschizomyces capitatus. I also exhibited strong activity against the trypomastigote form of Trypanosoma brucei rhodesiense and moderate activity against Trypanosoma cruzi. Testing against Plasmodium falciparum showed only weak activity. This is the 1st report on the in vitro fungicidal and antiprotozoal effects of justicidin B. In addn., both compds. exhibited a non-specific cytotoxicity in neoplastic and primary cell cultures. No antibacterial effects were detected. Both compds. were piscicidal against zebra fish and it is shown for the 1st time that I and II are the piscicidal principles of P. piscatorum, exhibiting a potency that is comparable to rotenone.
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