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Antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum

Gertsch, Juerg and Tobler, Rebekka Thoeni and Brun, Reto and Sticher, Otto and Heilmann, Jörg (2003) Antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum. Planta medica 69 (5), pp. 420-424.

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Abstract

Using activity against Candida albicans as a lead, the bioactivity-guided fractionation of the CH2Cl2 ext. of P. piscatorum led to the isolation of the arylnaphthalide lignan justicidin B (I), which was found to be present in high amts., and a new C-11 hydroxylated deriv. that we named piscatorin (II). We provide evidence that I is the main active principle of P. piscatorum, showing the same ...

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Item Type:Article
Date:2003
Additional information (public):CAN 139:377900 11-1 Plant Biochemistry 623943-73-7P (Piscatorin) Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum); 17951-19-8P (Justicidin B) Role: BSU (Biological study, unclassified), PUR (Purification or recovery), BIOL (Biological study), PREP (Preparation) (antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2003:512784Other
Keywords:Antibiotics Fungicides Phyllanthus piscatorum Protozoacides (antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum) Toxins Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (cytotoxins antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum) Molecular structure (of piscatorin (arylnaphthalide lignan) New natural products (piscatorin (arylnaphthalide lignan) Pesticides (piscicides antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum) Phyllanthus justicidin B piscatorin fungicide protozoacide cytotoxin piscicide
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Prof. Dr. Joerg Heilmann
Deposited On:18 Oct 2010 12:29
Last Modified:18 Oct 2010 12:29
Item ID:17213
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