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Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-Type sesquiterpene lactones

Hilmi, Fatima und Gertsch, Jurg und Bremner, Paul und Valovic, Silvia und Heinrich, Michael und Sticher, Otto und Heilmann, Jörg (2003) Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-Type sesquiterpene lactones. Bioorganic & medicinal chemistry 11 (17), S. 3659-3663.

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Zusammenfassung

Four guaianolide type sesquiterpene lactones (SL), namely the new 1,2-dihydro-3-oxo-costic acid guaianyl ester 3beta -O-(1,2-didehydro-3-oxo-costoyloxy)-4beta ,10beta -dihydroxy-guaia-1(2)-en-6beta ,12-olide (1) and 3beta -O-(1,2-didehydro-3-oxo-costoyloxy)-4beta ,10beta -dihydroxy-guaia-1(2)-en-6alpha ,12-olide (2), as well as the known moroccolide A [5alpha H-2beta ,4-epoxy-3beta ...

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Dokumentenart:Artikel
Datum:2003
Zusätzliche Informationen (Öffentlich):CAN 140:125216 11-1 Plant Biochemistry 83869-56-1 (GM-CSF) Role: BSU (Biological study, unclassified), BIOL (Biological study) (cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones); 648891-46-7; 648891-47-8 Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PRP (Properties), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), USES (Uses) (cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones); 427893-96-7 (3beta -O-(2-Methylbutyryl)-moroccolide A); 427893-97-8 (Moroccolide A) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2003:595165Andere
Stichwörter / Keywords:Transcription factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (NF-kB (nuclear factor of k light chain gene enhancer in B-cells) cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones) Anti-inflammatory agents Cytotoxicity Human Inflammation Transcriptional regulation Warionia saharae (cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones) Interleukin 1beta Interleukin 2 Interleukin 6 Natural products Tumor necrosis factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones) Sesquiterpenes Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PRP (Properties), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), USES (Uses) (lactones cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones) Molecular structure (of sesquiterpene lactones) New natural products (sesquiterpene lactones) Warionia sesquiterpene lactone antiinflammatory agent cytotoxicity
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Nein
Eingebracht am:18 Okt 2010 12:32
Zuletzt geändert:18 Okt 2010 12:32
Dokumenten-ID:17215
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