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Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-Type sesquiterpene lactones

Hilmi, Fatima and Gertsch, Jurg and Bremner, Paul and Valovic, Silvia and Heinrich, Michael and Sticher, Otto and Heilmann, Jörg (2003) Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-Type sesquiterpene lactones. Bioorganic & medicinal chemistry 11 (17), pp. 3659-3663.

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Abstract

Four guaianolide type sesquiterpene lactones (SL), namely the new 1,2-dihydro-3-oxo-costic acid guaianyl ester 3beta -O-(1,2-didehydro-3-oxo-costoyloxy)-4beta ,10beta -dihydroxy-guaia-1(2)-en-6beta ,12-olide (1) and 3beta -O-(1,2-didehydro-3-oxo-costoyloxy)-4beta ,10beta -dihydroxy-guaia-1(2)-en-6alpha ,12-olide (2), as well as the known moroccolide A [5alpha H-2beta ,4-epoxy-3beta ...

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Item Type:Article
Date:2003
Additional information (public):CAN 140:125216 11-1 Plant Biochemistry 83869-56-1 (GM-CSF) Role: BSU (Biological study, unclassified), BIOL (Biological study) (cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones); 648891-46-7; 648891-47-8 Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PRP (Properties), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), USES (Uses) (cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones); 427893-96-7 (3beta -O-(2-Methylbutyryl)-moroccolide A); 427893-97-8 (Moroccolide A) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2003:595165Other
Keywords:Transcription factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (NF-kB (nuclear factor of k light chain gene enhancer in B-cells) cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones) Anti-inflammatory agents Cytotoxicity Human Inflammation Transcriptional regulation Warionia saharae (cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones) Interleukin 1beta Interleukin 2 Interleukin 6 Natural products Tumor necrosis factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones) Sesquiterpenes Role: NPO (Natural product occurrence), PAC (Pharmacological activity), PRP (Properties), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), USES (Uses) (lactones cytotoxic vs. anti-inflammatory effects of guaianolide-type sesquiterpene lactones) Molecular structure (of sesquiterpene lactones) New natural products (sesquiterpene lactones) Warionia sesquiterpene lactone antiinflammatory agent cytotoxicity
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Prof. Dr. Joerg Heilmann
Deposited On:18 Oct 2010 12:32
Last Modified:18 Oct 2010 12:32
Item ID:17215
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