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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Zeitschrift für Naturforschung: Section C, A journal of biosciences | ||||
| Verlag: | Verl. d. Zeitschrift für Naturforschung | ||||
| Band: | 58 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 7/8 | ||||
| Seitenbereich: | S. 527-532 | ||||
| Datum: | 2003 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 140:178249 11-1 Plant Biochemistry 1617-70-5 (Lup-20(29)-en-3-one) Role: BSU (Biological study, unclassified), BIOL (Biological study) (antibacterial and cytotoxic activity of prenylated bicyclic acylphloroglucinol derivs. from Hypericum amblycalyx); 658702-60-4P (Hypercalyxone A); 658702-61-5P (Hypercalyxone B) Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (antibacterial and cytotoxic activity of prenylated bicyclic acylphloroglucinol derivs. from Hypericum amblycalyx); 658702-62-6P ((+)-1-[5,7-Dihydroxy-2-methyl-2-(4-methylpent-3-enyl)-chroman-8-yl]-2-methylpropan-1-one); 658702-63-7P ((+)-1-[5,7-Dihydroxy-2-methyl-2-(4-methylpent-3-enyl)-chroman-8-yl]-2-methylbutan-1-one) Role: BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), PREP (Preparation) (antibacterial and cytotoxic activity of prenylated bicyclic acylphloroglucinol derivs. from Hypericum amblycalyx) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Antibiotics Antitumor agents Hypericum amblycalyx (antibacterial and cytotoxic activity of prenylated bicyclic acylphloroglucinol derivs. from Hypericum amblycalyx) Toxins Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (cytotoxins antibacterial and cytotoxic activity of prenylated bicyclic acylphloroglucinol derivs. from Hypericum amblycalyx) New natural products (hypercalyxone A (bicyclic acylphloroglucinol deriv.) New natural products (hypercalyxone B (bicyclic acylphloroglucinol deriv.) Molecular structure (of hypercalyxones (bicyclic acylphloroglucinol derivs.) antibacterial cytotoxin prenylated bicyclic acylphloroglucinol deriv Hypericum | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Nein | ||||
| Dokumenten-ID: | 17219 |
Zusammenfassung
Two new bicyclic acylphloroglucinol derivs., hypercalyxone A (I) and B (II), were isolated from the petroleum ether ext. of the aerial parts of H. amblycalyx, together with 2 further compds. (1-[5,7-dihydroxy-2-methyl-2-(4-methylpent-3-enyl)-chroman-8-yl]-2-methylpropan-1-one [III] and 1-[5,7-dihydroxy-2-methyl-2-(4-methylpent-3-enyl)-chroman-8-yl]-2-methylbutan-1-one [IV]), which have been ...
Zusammenfassung
Two new bicyclic acylphloroglucinol derivs., hypercalyxone A (I) and B (II), were isolated from the petroleum ether ext. of the aerial parts of H. amblycalyx, together with 2 further compds. (1-[5,7-dihydroxy-2-methyl-2-(4-methylpent-3-enyl)-chroman-8-yl]-2-methylpropan-1-one [III] and 1-[5,7-dihydroxy-2-methyl-2-(4-methylpent-3-enyl)-chroman-8-yl]-2-methylbutan-1-one [IV]), which have been described only as semisynthetic products. In addn., the known triterpene lup-20(29)-en-3-one was obtained. Structure elucidation was based on 1D and 2D NMR studies, as well as on data derived from mass spectrometry. The 4 acylphloroglucinol derivs. were evaluated for their cytotoxic and antibacterial activity. All compds. showed moderate cytotoxic activity against KB and Jurkat T cancer cells. Esp. III and IV exhibited strong antibacterial activity against different Gram-pos. strains.
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