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Synthesis and biological activity of alpha-bromoacryloyl lexitropsin conjugates

Romagnoli, Romeo und Baraldi, Pier Giovanni und Iaconinoto, Maria Antonietta und Carrion, Maria Dora und Tabrizi, Mojgan Aghazadeh und Gambari, Roberto und Borgatti, Monica und Heilmann, Jörg (2005) Synthesis and biological activity of alpha-bromoacryloyl lexitropsin conjugates. European journal of medicinal chemistry 40 (11), S. 1123-1128.

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Zusammenfassung

The design, synthesis and biol. evaluation of lexitropsins bearing mixed heterocyclic and benzoheterocyclic moieties and tethered to an alpha-bromo acrylic moiety acting as alkylating moiety are reported, and structure-activity relationships detd. For example, indolecarboxylic acid I reacted with pyrrole deriv. II to give analog III (X = Y = CH, Z = NMe) in 63% yield. With respect to ...

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Dokumentenart:Artikel
Datum:2005
Zusätzliche Informationen (Öffentlich):CAN 144:23119 34-3 Amino Acids, Peptides, and Proteins 636-47-5 (Distamycin A); 132244-47-4; 287734-07-0 Role: PAC (Pharmacological activity), BIOL (Biological study) (prepn. of alpha -bromoacryloyl lexitropsin conjugates, their human antitumor activity, and structure-activity relationship); 870476-34-9P; 870476-35-0P; 870476-36-1P; 870476-37-2P; 870476-38-3P; 870476-39-4P; 870476-40-7P; 870476-41-8P; 870476-42-9P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. of alpha -bromoacryloyl lexitropsin conjugates, their human antitumor activity, and structure-activity relationship); 207845-97-4; 245358-71-8; 561318-70-5; 870476-43-0; 870476-44-1; 870476-45-2 Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of alpha -bromoacryloyl lexitropsin conjugates, their human antitumor activity, and structure-activity relationship)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2005:1119440Andere
Stichwörter / Keywords:Structure-activity relationship (antitumor prepn. of alpha -bromoacryloyl lexitropsin conjugates, their antitumor activity, and structure-activity relationship) Antitumor agents Cytotoxicity Leukemia (prepn. of alpha -bromoacryloyl lexitropsin conjugates, their antitumor activity, and structure-activity relationship) Human (prepn. of alpha -bromoacryloyl lexitropsin conjugates, their human antitumor activity, and structure-activity relationship) bromoacryloyl lexitropsin conjugate prepn antitumor structure activity lexitropsin heterocyclic benzoheterocyclic bromoacryloyl prepn antitumor structure activity human antitumor lexitropsin bromoacryloyl structure activity
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:18 Okt 2010 12:50
Zuletzt geändert:18 Okt 2010 12:50
Dokumenten-ID:17226
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