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Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum

Karioti, Anastasia and Skopeliti, Margarita and Tsitsilonis, Ourania and Heilmann, Jörg and Skaltsa, Helen (2007) Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum. Phytochemistry 68 (11), pp. 1587-1594.

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Abstract

From the aerial parts of Marrubium cylleneum, 1 labdane nor-diterpene was isolated together with 2 labdane diterpenes, hitherto not known as natural products. The structures of the isolated compds. were established by means of NMR [1H-1H-COSY, 1H-13C-HSQC, HMQC-TOCSY, HMBC, NOESY] and MS spectral analyses. Several diterpenoids from M. cylleneum and M. velutinum were tested for their cytotoxic ...

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Item Type:Article
Date:2007
Additional information (public):CAN 147:203316 1-6 Pharmacology 465-92-9P; 19898-90-9P; 19906-99-1P; 72010-01-6P; 72029-64-2P; 170554-74-2P; 175861-92-4P; 176019-14-0P; 857901-78-1P; 857901-80-5P; 858341-33-0P; 944795-71-5P; 944795-73-7P Role: PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (labdane diterpenes from Marrubium cylleneum and Marrubium velutinum, purifn., mol. structure, cytotoxicity, and immunomodulation)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2007:588022Other
Keywords:Antitumor agents Cytotoxicity Human Immunosuppressants Lymphocyte Marrubium cylleneum Marrubium velutinum Molecular structure Natural products (labdane diterpenes from Marrubium cylleneum and Marrubium velutinum, purifn., mol. structure, cytotoxicity, and immunomodulation) Diterpenes Role: PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (labdane labdane diterpenes from Marrubium cylleneum and Marrubium velutinum, purifn., mol. structure, cytotoxicity, and immunomodulation) Diterpenes Role: PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (norditerpenes labdane diterpenes from Marrubium cylleneum and Marrubium velutinum, purifn., mol. structure, cytotoxicity, and immunomodulation) labdane diterpene Marrubium mol structure cytotoxicity immunomodulator antitumor
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Dr. Joerg Heilmann
Deposited On:18 Oct 2010 13:18
Last Modified:18 Oct 2010 13:18
Item ID:17231
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