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Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum

Karioti, Anastasia and Skopeliti, Margarita and Tsitsilonis, Ourania and Heilmann, Jörg and Skaltsa, Helen (2007) Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum. Phytochemistry 68 (11), pp. 1587-1594.

Full text not available from this repository.

Abstract

From the aerial parts of Marrubium cylleneum, 1 labdane nor-diterpene was isolated together with 2 labdane diterpenes, hitherto not known as natural products. The structures of the isolated compds. were established by means of NMR [1H-1H-COSY, 1H-13C-HSQC, HMQC-TOCSY, HMBC, NOESY] and MS spectral analyses. Several diterpenoids from M. cylleneum and M. velutinum were tested for their cytotoxic effect against various cancer cell lines and their immunomodulating potential in human peripheral blood mononuclear cells in std. in vitro assays. The results show a differential cytotoxicity of some compds. as well as their ability to improve selected lymphocyte functions.

Item Type:

Article

Additional information (public):

CAN 147:203316 1-6 Pharmacology 465-92-9P; 19898-90-9P; 19906-99-1P; 72010-01-6P; 72029-64-2P; 170554-74-2P; 175861-92-4P; 176019-14-0P; 857901-78-1P; 857901-80-5P; 858341-33-0P; 944795-71-5P; 944795-73-7P Role: PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (labdane diterpenes from Marrubium cylleneum and Marrubium velutinum, purifn., mol. structure, cytotoxicity, and immunomodulation)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)

Identification Number:

Value	Type
2007:588022	Other

Keywords:

Antitumor agents Cytotoxicity Human Immunosuppressants Lymphocyte Marrubium cylleneum Marrubium velutinum Molecular structure Natural products (labdane diterpenes from Marrubium cylleneum and Marrubium velutinum, purifn., mol. structure, cytotoxicity, and immunomodulation) Diterpenes Role: PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (labdane labdane diterpenes from Marrubium cylleneum and Marrubium velutinum, purifn., mol. structure, cytotoxicity, and immunomodulation) Diterpenes Role: PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (norditerpenes labdane diterpenes from Marrubium cylleneum and Marrubium velutinum, purifn., mol. structure, cytotoxicity, and immunomodulation) labdane diterpene Marrubium mol structure cytotoxicity immunomodulator antitumor

Subjects:

500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Yes

Owner:

Prof. Dr. Joerg Heilmann

Deposited On:

18 Oct 2010 15:18