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Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates

Fang, Lei und Kraus, Birgit und Lehmann, Jochen und Heilmann, Jörg und Zhang, Yihua und Decker, Michael (2008) Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates. Bioorganic & medicinal chemistry letters 18 (9), S. 2905-2909.

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Zusammenfassung

Five tacrine-ferulic acid hybrids were designed and synthesized as multi-potent anti-Alzheimer drug candidates. All target compds. have better acetylcholinesterase inhibitory activity and comparable butyrylcholinesterase inhibitory activity in relation to tacrine. Interestingly, I showed a reversible and non-competitive inhibitory action for acetylcholinesterase indicating interaction with the ...

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Dokumentenart:Artikel
Datum:2008
Zusätzliche Informationen (Öffentlich):CAN 149:129007 31-5 Alkaloids 9000-81-1 (Acetylcholinesterase); 9001-08-5 (Cholinesterase) Role: BSU (Biological study, unclassified), BIOL (Biological study) (inhibitors; synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates); 321-64-2 (Tacrine); 1135-24-6 (Ferulic acid) Role: PAC (Pharmacological activity), BIOL (Biological study) (synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates); 57165-75-0P; 249290-07-1P; 249290-16-2P; 249290-19-5P; 844874-03-9P Role: PAC (Pharmacological activity), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates); 1036298-17-5P; 1036298-18-6P; 1036298-19-7P; 1036298-20-0P; 1036298-21-1P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates); 107-15-3 (1,2-Ethanediamine); 109-76-2 (1,3-Propanediamine); 110-60-1 (1,4-Butanediamine); 373-44-4 (1,8-Octanediamine); 462-94-2 (1,5-Pentanediamine); 537-98-4; 541-41-3; 5396-30-5 Role: RCT (Reactant), RACT (Reactant or reagent) (synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates); 62621-20-9P; 1036298-12-0P; 1036298-13-1P; 1036298-14-2P; 1036298-15-3P; 1036298-16-4P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2008:581025Andere
Stichwörter / Keywords:Structure-activity relationship (antioxidant synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates) Amines Role: PAC (Pharmacological activity), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (diamines synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates) Alkaloids Role: PAC (Pharmacological activity), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (quinoline synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates) Anti-Alzheimer's agents Cholinesterase inhibitors (synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates) tacrine ferulic acid hybrid synthesis cholinesterase inhibitor antioxidant agent anti Alzheimer agent tacrine ferulic acid hydrid
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:18 Okt 2010 13:31
Zuletzt geändert:18 Okt 2010 13:31
Dokumenten-ID:17239
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