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Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein Galpha i2beta 1gamma 2

Nickl, Kathrin and Gardner, Eric E. and Geiger, Sarah and Heilmann, Jörg and Seifert, Roland (2008) Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein Galpha i2beta 1gamma 2. Neuroscience letters 447 (1), pp. 68-72.

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Abstract

Human cannabinoid receptors 1 (hCB1R) and 2 (hCB2R) are expressed in the CNS and couple to Gi/Go-proteins. The aim of this study was to compare coupling of hCB1R and hCB2R to Galpha i2beta 1gamma 2 in Sf9 insect cells. High-affinity agonist binding at hCB1R, but not at hCB2R, was resistant to guanine nucleotides. HCB1R activated Galpha i2beta 1gamma 2 much more rapidly than hCB2R in the ...

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Item Type:Article
Date:2008
Additional information (public):CAN 150:48318 2-5 Mammalian Hormones 9059-32-9 (GTPase) Role: BSU (Biological study, unclassified), BIOL (Biological study) (activity regulation; differential coupling of human cannabinoid receptors hCB1R and hCB2R to G-protein Galpha i2beta 1gamma 2 point to distinct functions in central nervous system); 146-91-8 (5'-GDP); 37589-80-3 (GTPgamma S) Role: BSU (Biological study, unclassified), BIOL (Biological study) (binding; differential coupling of human cannabinoid receptors hCB1R and hCB2R to G-protein Galpha i2beta 1gamma 2 point to distinct functions in central nervous system)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
2008:1296410Other
Keywords:G proteins Role: BSU (Biological study, unclassified), BIOL (Biological study) (Gi2 (adenylate cyclase-inhibiting, 2), alpha subunit differential coupling of human cannabinoid receptors hCB1R and hCB2R to G-protein Galpha i2beta 1gamma 2 point to distinct functions in central nervous system) Central nervous system Human (differential coupling of human cannabinoid receptors hCB1R and hCB2R to G-protein Galpha i2beta 1gamma 2 point to distinct functions in central nervous system) Cannabinoid receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (type CB1 differential coupling of human cannabinoid receptors hCB1R and hCB2R to G-protein Galpha i2beta 1gamma 2 point to distinct functions in central nervous system) Cannabinoid receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (type CB2 differential coupling of human cannabinoid receptors hCB1R and hCB2R to G-protein Galpha i2beta 1gamma 2 point to distinct functions in central nervous system) G proteins Role: BSU (Biological study, unclassified), BIOL (Biological study) (beta 1gamma 2 subunits differential coupling of human cannabinoid receptors hCB1R and hCB2R to G-protein Galpha i2beta 1gamma 2 point to distinct functions in central nervous system) cannabinoid receptor CB1R CB2R Gi protein GTPase GDP GTP
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Dr. Joerg Heilmann
Deposited On:18 Oct 2010 13:33
Last Modified:26 Oct 2010 11:10
Item ID:17240
Owner Only: item control page
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