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Spontaneous Formation of Bilayers and Vesicles in Mixtures of Single-Chain Alkyl Carboxylates: Effect of pH and Aging and Cytotoxicity Studies

Vlachy, N. and Merle, C. and Touraud, D. and Schmidt, J. and Talmon, Y. and Heilmann, Jörg and Kunz, W. (2008) Spontaneous Formation of Bilayers and Vesicles in Mixtures of Single-Chain Alkyl Carboxylates: Effect of pH and Aging and Cytotoxicity Studies. Langmuir 24 (18), pp. 9983-9988.

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Abstract

We report the observation of bilayer fragments, some of which close to form vesicles, over a large range of pH at room temp. from mixts. of single-chain biocompatible com. available nontoxic alkyl carboxylic surfactants after neutralization with HCl. The pH at which the morphol. transitions occur is varied only by changing the ratio between two surfactants: the alkyloligoethyleneoxide carboxylate ...

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Item Type:Article
Date:2008
Additional information (public):CAN 149:362450 63-5 Pharmaceuticals 75-21-8D (Ethyleneoxide); 629-25-4 (Sodium laurate) Role: PEP (Physical, engineering or chemical process), PRP (Properties), PROC (Process) (spontaneous formation of bilayers and vesicles in mixts. of single-chain alkyl carboxylates, effect of pH and aging); 33939-64-9 (Akypo Soft 45NV) Role: PEP (Physical, engineering or chemical process), PRP (Properties), THU (Therapeutic use), BIOL (Biological study), PROC (Process), USES (Uses) (spontaneous formation of bilayers and vesicles in mixts. of single-chain alkyl carboxylates, effect of pH and aging)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2008:1004520Other
Keywords:Solubility (Temp. spontaneous formation of bilayers and vesicles in mixts. of single-chain alkyl carboxylates, effect of pH and aging) Carboxylic acids Role: PEP (Physical, engineering or chemical process), PRP (Properties), PROC (Process) (alkyl esters, single-chain, alkyloligoethyleneoxide spontaneous formation of bilayers and vesicles in mixts. of single-chain alkyl carboxylates, effect of pH and aging) Bilayer membranes Cytotoxicity Hydrogen bond Pharmaceutical liposomes Phase diagram Phase transition Self-assembly Vesicles pH (spontaneous formation of bilayers and vesicles in mixts. of single-chain alkyl carboxylates, effect of pH and aging) alkylcarboxylate sodium laurate bilayer vesicle selfassembly pH cytotoxicity topical
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Dr. Joerg Heilmann
Deposited On:18 Oct 2010 13:35
Last Modified:18 Oct 2010 13:35
Item ID:17241
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