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Spontaneous Formation of Bilayers and Vesicles in Mixtures of Single-Chain Alkyl Carboxylates: Effect of pH and Aging and Cytotoxicity Studies

Vlachy, N. und Merle, C. und Touraud, D. und Schmidt, J. und Talmon, Y. und Heilmann, Jörg und Kunz, W. (2008) Spontaneous Formation of Bilayers and Vesicles in Mixtures of Single-Chain Alkyl Carboxylates: Effect of pH and Aging and Cytotoxicity Studies. Langmuir 24 (18), S. 9983-9988.

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Zusammenfassung

We report the observation of bilayer fragments, some of which close to form vesicles, over a large range of pH at room temp. from mixts. of single-chain biocompatible com. available nontoxic alkyl carboxylic surfactants after neutralization with HCl. The pH at which the morphol. transitions occur is varied only by changing the ratio between two surfactants: the alkyloligoethyleneoxide carboxylate ...

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Dokumentenart:Artikel
Datum:2008
Zusätzliche Informationen (Öffentlich):CAN 149:362450 63-5 Pharmaceuticals 75-21-8D (Ethyleneoxide); 629-25-4 (Sodium laurate) Role: PEP (Physical, engineering or chemical process), PRP (Properties), PROC (Process) (spontaneous formation of bilayers and vesicles in mixts. of single-chain alkyl carboxylates, effect of pH and aging); 33939-64-9 (Akypo Soft 45NV) Role: PEP (Physical, engineering or chemical process), PRP (Properties), THU (Therapeutic use), BIOL (Biological study), PROC (Process), USES (Uses) (spontaneous formation of bilayers and vesicles in mixts. of single-chain alkyl carboxylates, effect of pH and aging)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2008:1004520Andere
Stichwörter / Keywords:Solubility (Temp. spontaneous formation of bilayers and vesicles in mixts. of single-chain alkyl carboxylates, effect of pH and aging) Carboxylic acids Role: PEP (Physical, engineering or chemical process), PRP (Properties), PROC (Process) (alkyl esters, single-chain, alkyloligoethyleneoxide spontaneous formation of bilayers and vesicles in mixts. of single-chain alkyl carboxylates, effect of pH and aging) Bilayer membranes Cytotoxicity Hydrogen bond Pharmaceutical liposomes Phase diagram Phase transition Self-assembly Vesicles pH (spontaneous formation of bilayers and vesicles in mixts. of single-chain alkyl carboxylates, effect of pH and aging) alkylcarboxylate sodium laurate bilayer vesicle selfassembly pH cytotoxicity topical
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:18 Okt 2010 13:35
Zuletzt geändert:18 Okt 2010 13:35
Dokumenten-ID:17241
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