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Antioxidant Effects of Xanthohumol and Functional Impact on Hepatic Ischemia-Reperfusion Injury

Hartkorn, Andreas and Hoffmann, Florian and Ajamieh, Hussam and Vogel, Susanne and Heilmann, Jörg and Gerbes, Alexander L. and Vollmar, Angelika M. and Zahler, Stefan (2009) Antioxidant Effects of Xanthohumol and Functional Impact on Hepatic Ischemia-Reperfusion Injury. Journal of natural products 72 (10), pp. 1741-1747.

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Abstract

Therapeutic effects of dietary flavonoids have been attributed mainly to their antioxidant capacity. Xanthohumol (1), a prominent flavonoid of the hop plant, Humulus lupulus, was investigated for its antioxidant potential and for its effect on NF-kB activation. To examine the biol. relevance of 1, a hepatic ischemia/reperfusion model was chosen as a widely accepted model of oxidative stress ...

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Item Type:Article
Date:2009
Additional information (public):CAN 151:396041 1-12 Pharmacology 70-18-8 (Glutathione); 7782-44-7D (Oxygen); 9000-86-6 (Alanine aminotransferase); 9000-97-9 (Aspartate aminotransferase); 148640-14-6 (Akt kinase); 169592-56-7 (Caspase-3) Role: BSU (Biological study, unclassified), BIOL (Biological study) (antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury); 6754-58-1 (Xanthohumol) Role: DMA (Drug mechanism of action), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2009:1149771Other
Keywords:Proteins Role: BSU (Biological study, unclassified), BIOL (Biological study) (Bcl-x antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Apoptosis Humulus lupulus Lipid peroxidation Oxidative stress Signal transduction (antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Reactive oxygen species Transcription factor NF-kB Tumor necrosis factors Role: BSU (Biological study, unclassified), BIOL (Biological study) (antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Flavonoids Role: DMA (Drug mechanism of action), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Injury Ischemia (hepatic antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Cytoprotective agents (hepatoprotective agents antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Liver disease (injury antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Liver disease (ischemia antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Antioxidants (natural antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) Phosphorylation (protein antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury) antioxidant xanthohumol hepatoprotectant liver ischemia reperfusion injury oxidative stress
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Dr. Joerg Heilmann
Deposited On:18 Oct 2010 13:51
Last Modified:18 Oct 2010 13:51
Item ID:17244
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