Bradacs, Gesine and Maes, Louis and Heilmann, Jörg (2010) In vitro cytotoxic, antiprotozoal and antimicrobial activities of medicinal plants from Vanuatu. Phytotherapy research 24 (6), pp. 800-809.
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Sixty-three extracts obtained from 18 plants traditionally used in the South Pacific archipelago Vanuatu for the treatment of infectious diseases were screened for antimicrobial and antiprotozoal activities. In addition, the extracts were subjected to a detailed analysis on cytotoxic effects toward a panel of human cancer cell lines, designed as a smaller version of the NCI60 screen. Intriguingly, 15 plant extracts exhibited strong cytotoxic effects specific for only one cancer cell line. Extracts of the leaves of Acalypha grandis Benth. significantly affected Plasmodium falciparum without showing obvious effects against the other protozoa tested. The leaves of Gyrocarpus americanus Jacq. displayed significant activity against Trypanosoma b. brucei and the leaves of Tabernaemontana pandacaqui Lam. I as well as the stems of Macropiper latifolium (L.f.) against Trypanosoma cruzi. In contrast none of the extracts showed relevant antibacterial or antifungal activity. (c) 2009 John Wiley & Sons, Ltd.
|Additional information (public):||England: United Kingdom|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)|
|Keywords:||*Anti-Infective Agents: PD, pharmacology *Antineoplastic Agents, Phytogenic: PD, pharmacology *Antiprotozoal Agents: PD, pharmacology Cell Line, Tumor Humans Microbial Sensitivity Tests Parasitic Sensitivity Tests *Plant Extracts: PD, pharmacology Plant Leaves: CH, chemistry *Plants, Medicinal: CH, chemistry Vanuatu 0 (Anti-Infective Agents) 0 (Antineoplastic Agents, Phytogenic) 0 (Antiprotozoal Agents) 0 (Plant Extracts)|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Owner:||Prof. Dr. Joerg Heilmann|
|Deposited On:||18 Oct 2010 13:57|
|Last Modified:||18 Oct 2010 13:57|