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Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis

Dorn, Christoph and Kraus, Birgit and Motyl, Magdalena and Weiss, Thomas S. and Gehrig, Manfred and Schoelmerich, Juergen and Heilmann, Jörg and Hellerbrand, Claus (2010) Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis. Molecular nutrition & food research 54 (Suppl. 2), S205-S213.

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Xanthohumol (XN) is a major prenylated chalcone found in hops, which is used to add bitterness and flavor to beer. In this study, we first investigated the effects of XN on hepatocytes and hepatic stellate cells (HSC), the central mediators of liver fibrogenesis. XN inhibited the activation of primary human HSC and induced apoptosis in activated HSC in vitro in a dose dependent manner (0-20 micro ...


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Item Type:Article
Additional Information (public):1 Pharmacology
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:18 Oct 2010 14:16
Last Modified:18 Oct 2010 14:16
Item ID:17250
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