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Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis

Dorn, Christoph and Kraus, Birgit and Motyl, Magdalena and Weiss, Thomas S. and Gehrig, Manfred and Schoelmerich, Juergen and Heilmann, Jörg and Hellerbrand, Claus (2010) Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis. Molecular nutrition & food research 54 (Suppl. 2), S205-S213.

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Abstract

Xanthohumol (XN) is a major prenylated chalcone found in hops, which is used to add bitterness and flavor to beer. In this study, we first investigated the effects of XN on hepatocytes and hepatic stellate cells (HSC), the central mediators of liver fibrogenesis. XN inhibited the activation of primary human HSC and induced apoptosis in activated HSC in vitro in a dose dependent manner (0-20 micro ...

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Export bibliographical data

Item Type:Article
Date:2010
Additional information (public):1 Pharmacology
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2010:939101Other
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Dr. Joerg Heilmann
Deposited On:18 Oct 2010 14:16
Last Modified:18 Oct 2010 14:16
Item ID:17250
Owner Only: item control page
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