Dorn, Christoph and Kraus, Birgit and Motyl, Magdalena and Weiss, Thomas S. and Gehrig, Manfred and Schoelmerich, Juergen and Heilmann, Jörg and Hellerbrand, Claus (2010) Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis. Molecular nutrition & food research 54 (Suppl. 2), S205-S213.
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Xanthohumol (XN) is a major prenylated chalcone found in hops, which is used to add bitterness and flavor to beer. In this study, we first investigated the effects of XN on hepatocytes and hepatic stellate cells (HSC), the central mediators of liver fibrogenesis. XN inhibited the activation of primary human HSC and induced apoptosis in activated HSC in vitro in a dose dependent manner (0-20 micro M). In contrast, XN doses as high as 50 micro M did not impair viability of primary human hepatocytes. However, in both cell types XN inhibited activation of the transcription factor NFkB and expression of NFkB dependent proinflammatory genes. In vivo, feeding of XN reduced hepatic inflammation and expression of profibrogenic genes in a murine model of non-alc. steatohepatitis. These data indicate that XN has the potential as functional nutrient for the prevention or treatment of non-alc. steatohepatitis or other chronic liver disease.
|Additional information (public):||1 Pharmacology|
|Institutions:|| Medicine > Lehrstuhl für Innere Medizin I|
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Owner:||Prof. Dr. Joerg Heilmann|
|Deposited On:||18 Oct 2010 16:16|
|Last Modified:||18 Oct 2010 16:16|
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