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Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells

Dorn, Christoph und Weiss, Thomas S. und Heilmann, Jörg und Hellerbrand, Claus (2010) Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells. International journal of oncology 36 (2), S. 435-441.

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Zusammenfassung

Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. Here, we show that xanthohumol at a concn. of 25 micro M induced apoptosis in two HCC cell lines (HepG2 and Huh7). Furthermore, xanthohumol repressed ...

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Dokumentenart:Artikel
Datum:2010
Zusätzliche Informationen (Öffentlich):CAN 153:221485 1-6 Pharmacology 6754-58-1 (Xanthohumol) Role: NPO (Natural product occurrence), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), USES (Uses) (xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell)
Institutionen:Medizin > Lehrstuhl für Innere Medizin I
Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2010:219362Andere
Stichwörter / Keywords:Cytotoxic agents (antiinflammatory xanthohumol inhibited interleukin-8 expression in human hepatocellular carcinoma cell) Carcinoma (hepatocellular xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Liver (hepatoma xanthohumol inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Antitumor agents (prenylated chalcone xanthohumol derived from Humulus lupulus inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Human Humulus lupulus Natural products (xanthohumol derived from Humulus lupulus inhibited proliferation, migration and interleukin-8 expression in human hepatocellular carcinoma cell) Apoptosis (xanthohumol induced apoptosis in human hepatocellular carcinoma cell) Interleukin 8 Role: BSU (Biological study, unclassified), BIOL (Biological study) (xanthohumol inhibited interleukin-8 expression in human hepatocellular carcinoma cell) Cell migration (xanthohumol inhibited migration in human hepatocellular carcinoma cell) Transcription factor NF-kB Role: BSU (Biological study, unclassified), BIOL (Biological study) (xanthohumol inhibited nuclear factor k-B activation in human hepatocellular carcinoma cell) interleukin hepatocellular carcinoma cytotoxic xanthohumol Humulus
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:18 Okt 2010 14:02
Zuletzt geändert:18 Okt 2010 14:02
Dokumenten-ID:17251
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