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Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands

Geiger, Sarah and Nickl, Kathrin and Schneider, Erich H. and Seifert, Roland and Heilmann, Jörg (2010) Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands. Naunyn-Schmiedebergs Archiv für Pharmakologie 382 (2), pp. 177-191.

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Abstract

Cannabinoid receptors (CBR) are important drug targets for the treatment of various inflammatory, metabolic and neurol. diseases. Therefore, sensitive test systems for the assessment of ligands are needed. In this study, a steady-state GTPase assay for human CBR subtypes 1 and 2 was developed to characterize the pharmacol. property of ligands at a very proximal point of the signal transduction ...

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Item Type:Article
Date:2010
Additional information (public):1 Pharmacology
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
2010:893445Other
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Dr. Joerg Heilmann
Deposited On:18 Oct 2010 14:04
Last Modified:26 Oct 2010 11:04
Item ID:17252
Owner Only: item control page
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