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The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat

Monti, J. M. and Jantos, H. and Leschke, C. and Elz, Sigurd and Schunack, W. (1994) The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat. European neuropsychopharmacology 4 (4), pp. 459-462.

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The effects of the selective histamine H1-receptor agonist, 2-(3-trifluoromethylphenyl)histamine, were studied in rats implanted with electrodes for chronic sleep recordings. 2-(3-Trifluoromethylphenyl)histamine (80-120 micrograms) injected into the left lateral ventricle increased wakefulness, whereas slow wave sleep was reduced. Pretreatment with pyrilamine (2.0 mg/kg) prevented the effects of ...


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Item type:Article
Additional Information (public):Monti, J M Jantos, H Leschke, C Elz, S Schunack, W Netherlands European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Eur Neuropsychopharmacol. 1994 Dec;4(4):459-62.
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Identification Number:
Keywords:Animals Dose-Response Relationship, Drug Electrodes, Implanted Histamine/administration & dosage/*analogs & derivatives/pharmacology Histamine Agonists/administration & dosage/*pharmacology Injections, Intraventricular Male Pyrilamine/pharmacology Rats Rats, Wistar Sleep/drug effects Wakefulness/*drug effects
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Deposited on:19 Oct 2010 12:20
Last modified:19 Oct 2010 12:20
Item ID:17290
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