Monti, J. M. and Jantos, H. and Leschke, C. and Elz, Sigurd and Schunack, W. (1994) The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat. European neuropsychopharmacology 4 (4), pp. 459-462.
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The effects of the selective histamine H1-receptor agonist, 2-(3-trifluoromethylphenyl)histamine, were studied in rats implanted with electrodes for chronic sleep recordings. 2-(3-Trifluoromethylphenyl)histamine (80-120 micrograms) injected into the left lateral ventricle increased wakefulness, whereas slow wave sleep was reduced. Pretreatment with pyrilamine (2.0 mg/kg) prevented the effects of the H1-receptor agonist on wakefulness and slow wave sleep. Our results further support the involvement of histamine in the modulation of the waking state.
|Additional information (public):||Monti, J M Jantos, H Leschke, C Elz, S Schunack, W Netherlands European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Eur Neuropsychopharmacol. 1994 Dec;4(4):459-62.|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)|
|Keywords:||Animals Dose-Response Relationship, Drug Electrodes, Implanted Histamine/administration & dosage/*analogs & derivatives/pharmacology Histamine Agonists/administration & dosage/*pharmacology Injections, Intraventricular Male Pyrilamine/pharmacology Rats Rats, Wistar Sleep/drug effects Wakefulness/*drug effects|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||No|
|Owner:||Prof. Dr. Sigurd Elz|
|Deposited On:||19 Oct 2010 12:20|
|Last Modified:||19 Oct 2010 12:20|