Deutsch
Monti, J. M. and Jantos, H. and Leschke, C. and Elz, Sigurd and Schunack, W. (1994) The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat. European neuropsychopharmacology 4 (4), pp. 459-462.
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Other URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7894255
Abstract
The effects of the selective histamine H1-receptor agonist, 2-(3-trifluoromethylphenyl)histamine, were studied in rats implanted with electrodes for chronic sleep recordings. 2-(3-Trifluoromethylphenyl)histamine (80-120 micrograms) injected into the left lateral ventricle increased wakefulness, whereas slow wave sleep was reduced. Pretreatment with pyrilamine (2.0 mg/kg) prevented the effects of the H1-receptor agonist on wakefulness and slow wave sleep. Our results further support the involvement of histamine in the modulation of the waking state.
| Item Type: | Article | ||||
|---|---|---|---|---|---|
| Additional information (public): | Monti, J M Jantos, H Leschke, C Elz, S Schunack, W Netherlands European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Eur Neuropsychopharmacol. 1994 Dec;4(4):459-62. | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) | ||||
| Identification Number: |
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| Keywords: | Animals Dose-Response Relationship, Drug Electrodes, Implanted Histamine/administration & dosage/*analogs & derivatives/pharmacology Histamine Agonists/administration & dosage/*pharmacology Injections, Intraventricular Male Pyrilamine/pharmacology Rats Rats, Wistar Sleep/drug effects Wakefulness/*drug effects | ||||
| Subjects: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | No | ||||
| Owner: | Prof. Dr. Sigurd Elz | ||||
| Deposited On: | 19 Oct 2010 14:20 | ||||
| Last Modified: | 19 Oct 2010 14:20 | ||||
| Item ID: | 17290 |
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