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Histamine analogues, XXXV: 2-substituted histamine derivatives containing classical moieties of H2-antagonists--a novel class of H1-agonists

Zingel, V. and Elz, Sigurd and Schunack, W. (1993) Histamine analogues, XXXV: 2-substituted histamine derivatives containing classical moieties of H2-antagonists--a novel class of H1-agonists. Archiv der Pharmazie 326 (3), pp. 143-151.

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Other URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8097625


Abstract

A new type of H1-agonists resulted from the combination of the essential histamine structure with parts of H2-antagonists. 2,4-Disubstituted imidazole derivatives were synthesized by reaction of imidic acid methyl esters with 1,3-dihydroxypropanone, 1,4-dihydroxybutanone or 2-oxo-4-phthalimido-1-butylacetate in liquid NH3. The imidazole intermediates were converted into histamine analogues by ...

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Item Type:Article
Date:1993
Additional information (public):Zingel, V Elz, S Schunack, W In Vitro Germany Archiv der Pharmazie Arch Pharm (Weinheim). 1993 Mar;326(3):143-51.
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Identification Number:
ValueType
8097625Other
Keywords:Animals Guinea Pigs Heart Atria/drug effects Histamine/*analogs & derivatives/chemical synthesis/pharmacology Histamine Agonists/*chemical synthesis/pharmacology Histamine H2 Antagonists/*chemical synthesis/pharmacology Muscle, Smooth/drug effects Structure-Activity Relationship
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Owner: Prof. Dr. Sigurd Elz
Deposited On:19 Oct 2010 12:24
Last Modified:19 Oct 2010 12:24
Item ID:17292
Owner Only: item control page
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