Elz, Sigurd and Schunack, W. (1988) [H2-antagonistic activity of the impromidine analog, cyanoguanidine. 37. H2 antihistaminics]. Arzneimittelforschung 38 (1), pp. 7-10.
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In studies on structure-activity relationships among impromidine-like histamine H2-receptor agonists, the synthesis of impromidine analogous guanidines led to the corresponding intermediate cyanoguanidines. The latter are structurally related to cimetidine. For that reason they were tested for H2-antagonistic activity on the isolated guinea-pig atrium. Compound 5h proved to be significantly more potent than cimetidine. Derivatives with branched thioether moiety were devoid of affinity. The results are consistent with existing structure-activity relationships.
|Additional information (public):||Elz, S Schunack, W English Abstract In Vitro Research Support, Non-U.S. Gov't Germany, west Arzneimittel-Forschung Arzneimittelforschung. 1988 Jan;38(1):7-10.|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)|
|Keywords:||Animals Chemistry Guanidines/*pharmacology Guinea Pigs Heart/*drug effects *Histamine H2 Antagonists Imidazoles/*pharmacology Impromidine Structure-Activity Relationship|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||No|
|Owner:||Prof. Dr. Sigurd Elz|
|Deposited On:||19 Oct 2010 12:30|
|Last Modified:||19 Oct 2010 12:30|