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G protein-coupled receptors function as logic gates for nanoparticle binding and cell uptake

Hild, Wolfgang and Pollinger, Klaus and Caporale, Andrea and Cabrele, Chiara and Keller, Max and Pluym, Nicola and Buschauer, Armin and Rachel, Reinhard and Tessmar, Joerg and Breunig, Miriam and Goepferich, Achim (2010) G protein-coupled receptors function as logic gates for nanoparticle binding and cell uptake. Proceedings of the National Academy of Sciences USA: PNAS 107 (23), pp. 10667-10672.

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Other URL: http://www.pnas.org/content/107/23/10667.short


More selective interactions of nanoparticles with cells would substantially increase their potential for diagnostic and therapeutic applications. Thus, it would not only be highly desirable that nanoparticles can be addressed to any cell with high target specificity and affinity, but that we could unequivocally define whether they rest immobilized on the cell surface as a diagnostic tag, or if ...


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Item type:Article
Date:8 June 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
10.1073/pnas.0912782107 DOI
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
600 Technology > 615 Pharmacy
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited on:22 Oct 2010 08:56
Last modified:07 Jul 2012 07:38
Item ID:17435
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