Deutsch
Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst (1977) cis-Dichloropeptide ester-platinum(II) complexes.
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Abstract
Peptide complexes I (R, R1 = H, C1-4 alkyl, optionally substituted by OH, NH2, OMe, OEt, SH, SMe, SEt, CH2Ph, CH2C6H4OH, CH2C6H4OMe, CH2C6H4OEt; R2 = C1-4 alkyl; n = 1-3) were prepd. Thus cis-PtCl2(Gly-OH)2 was treated with 4-O2NC6H4OH and cis-PtCl2(Gly-OC6H4NO2-4)2 treated with H-Gly-OEt to give cis-PtCl2(Gly-Gly-OEt)2 (I). I had a min. inhibitory concn. against Escherichia coli B of 5 * 10-4 mol/L and inhibited DNA synthesis in Walker 256 carcinosarcoma at 4.5 * 10-7 mol/L.
| Item Type: | Patent | ||||||
|---|---|---|---|---|---|---|---|
| Additional information (public): | CAN 88:170495 34-3 Synthesis of Amino Acids, Peptides, and Proteins Patent 19771229 2087-41-4; 66156-95-4 Role: RCT (Reactant), RACT (Reactant or reagent) (complexation of, with chloroplatinate); 10025-99-7 Role: RCT (Reactant), RACT (Reactant or reagent) (complexation of, with dipeptides); 60426-60-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and bactericidal and carcinostatic activity of); 60426-61-1P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and peptide synthesis with); 60399-28-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 100-02-7; 459-73-4; 26348-61-8 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with glycine platinum complex); 17567-45-2 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with nitrophenol) | ||||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger | ||||||
| Projects: | SFB 234 | ||||||
| Identification Number: |
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| Keywords: | Bactericides, Disinfectants and Antiseptics (glycylglycine platinum complex) Neoplasm inhibitors (Walker 256 carcinosarcoma, glycylglycine platinum complex) Neoplasm inhibitors (sarcoma 180, glycylglycine platinum complex) Neoplasm inhibitors (yoshidasarcoma, glycylglycine platinum complex) peptide platinum chloride complex bactericide glycylglycine platinum complex carcinostat glycylglycine platinum complex | ||||||
| Subjects: | 500 Science > 540 Chemistry & allied sciences | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Yes | ||||||
| Owner: | Petra Gürster | ||||||
| Deposited On: | 15 Nov 2010 16:04 | ||||||
| Last Modified: | 15 Nov 2010 16:04 | ||||||
| Item ID: | 17624 |
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