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cis-Dichloropeptide ester-platinum(II) complexes

Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst (1977) cis-Dichloropeptide ester-platinum(II) complexes.

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Abstract

Peptide complexes I (R, R1 = H, C1-4 alkyl, optionally substituted by OH, NH2, OMe, OEt, SH, SMe, SEt, CH2Ph, CH2C6H4OH, CH2C6H4OMe, CH2C6H4OEt; R2 = C1-4 alkyl; n = 1-3) were prepd. Thus cis-PtCl2(Gly-OH)2 was treated with 4-O2NC6H4OH and cis-PtCl2(Gly-OC6H4NO2-4)2 treated with H-Gly-OEt to give cis-PtCl2(Gly-Gly-OEt)2 (I). I had a min. inhibitory concn. against Escherichia coli B of 5 * 10-4 ...

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Item Type:Patent
Date:1977
Additional information (public):CAN 88:170495 34-3 Synthesis of Amino Acids, Peptides, and Proteins Patent 19771229 2087-41-4; 66156-95-4 Role: RCT (Reactant), RACT (Reactant or reagent) (complexation of, with chloroplatinate); 10025-99-7 Role: RCT (Reactant), RACT (Reactant or reagent) (complexation of, with dipeptides); 60426-60-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and bactericidal and carcinostatic activity of); 60426-61-1P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and peptide synthesis with); 60399-28-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 100-02-7; 459-73-4; 26348-61-8 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with glycine platinum complex); 17567-45-2 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with nitrophenol)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1978:170495Other
76-2626559 2626559Other
Keywords:Bactericides, Disinfectants and Antiseptics (glycylglycine platinum complex) Neoplasm inhibitors (Walker 256 carcinosarcoma, glycylglycine platinum complex) Neoplasm inhibitors (sarcoma 180, glycylglycine platinum complex) Neoplasm inhibitors (yoshidasarcoma, glycylglycine platinum complex) peptide platinum chloride complex bactericide glycylglycine platinum complex carcinostat glycylglycine platinum complex
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:15 Nov 2010 15:04
Last Modified:15 Nov 2010 15:04
Item ID:17624
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