Zeisler, R. and Lux, F. and Seidenberger, H. and Schönenberger, Helmut and Beck, W. (1979) Studies on the distribution of platinum in tumor-bearing rats after the administration of platinum co-ordination complexes used in cancer chemotherapy. In: Nuclear activation techniques in the life sciences 1978: proceedings of a Symposium on Nuclear Activation Techniques in the Life Sciences held by the International Atomic Energy Organsation in Vienna, 22-26 May 1978. Publication / Division of Scientific and Technical Information, International Atomic Energy Agency, 492. International Atomic Energy Agency, Vienna, pp. 467-477. ISBN 92-0-010079-1.
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After the administration of cis-Pt (gly-gly-OEt)2Cl2 complex [60426-60-0] (80 mg/kg and 0.8 mg/kg) to tumor-bearing rats, instrumental neutron activation anal. showed selective uptake of Pt by the ascitic carcinosarcoma cells and significant retention of Pt by the kidney. These findings confirm the drug's usefulness as an antitumor agent and suggest the possibility of nephrotoxicity.
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|Item Type:||Book Section|
|Additional Information (public):||CAN 92:104038 1-2 Pharmacodynamics 7440-06-4 Role: BIOL (Biological study) (uptake of, by tumor and organs, after platinum coordination complex administration); 60426-60-0 Role: PROC (Process) (uptake of, by tumor cells and organs)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Kidney Neoplasm Organ (platinum complex uptake by) platinum complex tumor uptake antitumor platinum complex kidney uptake|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||15 Nov 2010 14:11|
|Last Modified:||15 Nov 2010 14:11|