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Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes

Hartmann, Rolf W. and Buchborn, Helga and Kranzfelder, Gerhard and Schönenberger, Helmut and Bogden, Arthur E. (1981) Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes. Journal of medicinal chemistry 24 (10), pp. 1192-1197.

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Abstract

The syntheses of the meso-1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes [alkyl substituent: CH3 (I) [78682-42-5], C2H5 (II) [71953-72-5], C3H7 (III) [78682-43-6], C4H9 (IV) [78682-44-7], i-C4H9 (V) [78682-45-8], and C5H11 (VI) [78682-46-9]] and of d,l-3,4-bis(3'-hydroxyphenyl)hexane [71953-71-4] are described. In vitro these compds. inhibited the 3H-labeled estradiol [50-28-2] receptor interaction ...

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Item Type:Article
Date:1981
Additional information (public):CAN 95:126403 2-3 Hormone Pharmacology 591-31-1 Role: RCT (Reactant), RACT (Reactant or reagent) (alkylation of); 71953-71-4P; 71953-72-5P; 78682-42-5P; 78682-43-6P; 78682-44-7P; 78682-45-8P; 78682-46-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and antiestrogenic and neoplasm-inhibiting activity of); 1678-03-1P; 23308-82-9P; 52956-27-1P; 60441-55-6P; 68266-37-5P; 78682-47-0P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and chlorination of); 68266-39-7P; 71953-69-0P; 78682-40-3P; 78682-41-4P; 78682-49-2P; 78682-50-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and ether cleavage of); 1742-00-3P; 58114-05-9P; 68266-31-9P; 68266-35-3P; 68266-38-6P; 78682-48-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reductive coupling of); 50-28-2 Role: BIOL (Biological study) (receptor binding of, dialkylbis(hydroxyphenyl)ethanes inhibition of); 53-16-7 Role: BIOL (Biological study) (uterus growth stimulation by, dialkylbis(hydroxyphenyl)ethanes inhibition of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1981:526403Other
Keywords:Neoplasm inhibitors (dialkylbis(hydroxyphenyl)ethanes as) Receptors Role: BIOL (Biological study) (estradiol binding by, dialkylbis(hydroxyphenyl)ethanes inhibition of) Estrogens Role: BSU (Biological study, unclassified), BIOL (Biological study) (inhibitors, dialkylbis(hydroxyphenyl)ethanes as) Molecular structure-biological activity relationship (antiestrogenic, of dialkylbis(hydroxyphenyl)ethanes) Mammary gland (neoplasm, dialkylbis(hydroxyphenyl)ethanes inhibition of) Molecular structure-biological activity relationship (neoplasm-inhibiting, of dialkylbis(hydroxyphenyl)ethanes) alkylbishydroxyphenylethane prepn antiestrogen phenylethane dialkylbishydroxy antiestrogen antitumor estrogen inhibitor dialkylbishydroxyphenylethane neoplasm inhibitor dialkylbishydroxyphenylethane
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 09:34
Last Modified:12 Nov 2010 09:34
Item ID:17628
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