Michel, R. T. and Schönenberger, Helmut (1981) Effects of new anti-estrogens on serially transplanted human breast carcinomas in nude mice. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 199-204. ISBN 3-437-10683-X; 0-89574-154-7 .
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The effects of the estrogen 4,4'-DES-epoxide and the antistrogens, 3,3'-DES-epoxide, 3,3'-dihydroxy-alpha ,beta -diethylstilbene, and 3,4-di(hydroxyphenyl)hexane, were studied on estrogen and progesterone-contg. pre- and postmenopausal serially transplanted human breast tumors in nude mice. Treatment of premenopausal tumors with the 4 steroids or ovariectomy plus aminoglutethimide plus tamoxifen [10540-29-1] or aminoglutethimide plus tamoxifen was without effect on tumor growth. However, in postmenopausal tumor the 4 steroids markedly decreased tumor growth. Evidently, these antiestrogens were effective against postmenopausal but not premenopausal breast tumor growth.
|Item Type:||Book Section|
|Additional information (public):||CAN 96:174613 2-4 Mammalian Hormones 68266-24-0; 80149-87-7; 80944-70-3; 80944-71-4 Role: BIOL (Biological study) (mammary gland carcinoma of humans inhibition by, after menopause); 10540-29-1 Role: BIOL (Biological study) (mammary gland carcinoma of humans response to, menopause in relation to)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Neoplasm inhibitors (antiestrogens) Menopause (antiestrogens and estrogens effect on mammary carcinoma in humans in relation to) Estrogens Role: BIOL (Biological study) (inhibitors and, mammary gland carcinoma of humans response to, menopause in relation to) Carcinoma (of mammary gland, antiestrogen and estrogen inhibition of, after menopause in women) Mammary gland (neoplasm, carcinoma, antiestrogen and estrogen inhibition of, after menopause in women) breast tumor estrogen antiestrogen mammary carcinoma antiestrogen menopause|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||15 Nov 2010 15:18|
|Last Modified:||15 Nov 2010 15:18|
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