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Effects of new anti-estrogens on serially transplanted human breast carcinomas in nude mice

Michel, R. T. and Schönenberger, Helmut (1981) Effects of new anti-estrogens on serially transplanted human breast carcinomas in nude mice. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 199-204. ISBN 3-437-10683-X; 0-89574-154-7 .

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Abstract

The effects of the estrogen 4,4'-DES-epoxide and the antistrogens, 3,3'-DES-epoxide, 3,3'-dihydroxy-alpha ,beta -diethylstilbene, and 3,4-di(hydroxyphenyl)hexane, were studied on estrogen and progesterone-contg. pre- and postmenopausal serially transplanted human breast tumors in nude mice. Treatment of premenopausal tumors with the 4 steroids or ovariectomy plus aminoglutethimide plus tamoxifen [10540-29-1] or aminoglutethimide plus tamoxifen was without effect on tumor growth. However, in postmenopausal tumor the 4 steroids markedly decreased tumor growth. Evidently, these antiestrogens were effective against postmenopausal but not premenopausal breast tumor growth.

Item Type:

Book Section

Additional information (public):

CAN 96:174613 2-4 Mammalian Hormones 68266-24-0; 80149-87-7; 80944-70-3; 80944-71-4 Role: BIOL (Biological study) (mammary gland carcinoma of humans inhibition by, after menopause); 10540-29-1 Role: BIOL (Biological study) (mammary gland carcinoma of humans response to, menopause in relation to)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

Projects:

SFB 234

Identification Number:

Value	Type
1982:174613	Other

Keywords:

Neoplasm inhibitors (antiestrogens) Menopause (antiestrogens and estrogens effect on mammary carcinoma in humans in relation to) Estrogens Role: BIOL (Biological study) (inhibitors and, mammary gland carcinoma of humans response to, menopause in relation to) Carcinoma (of mammary gland, antiestrogen and estrogen inhibition of, after menopause in women) Mammary gland (neoplasm, carcinoma, antiestrogen and estrogen inhibition of, after menopause in women) breast tumor estrogen antiestrogen mammary carcinoma antiestrogen menopause

Subjects:

500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Yes

Owner:

Petra Gürster

Deposited On:

15 Nov 2010 15:18