Seidenberger, Horst and Kranzfelder, Gerhard and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth, Michael (1981) Studies on the mammary tumor inhibiting effect of cis-bis(glycylglycin ethyl ester)platinum(II) chloride. Archiv der Pharmazie 314 (11), pp. 955-967.
Full text not available from this repository.
In vivo, cis-dichlorodiammineplatinum(II) (I) [15663-27-1] and cis-dichlorobis(glycylglycine Et ester)platinum(II) (II) [60426-60-0] inhibited the DMBA-induced hormone-dependent mammary carcinoma of the SD rat. In vitro, a marked effect on DNA synthesis by mammary tumor cells and an inhibition of estradiol-receptor interaction by I and II were demonstrated. Binding to DNA and inhibition of the proliferation-stimulating effect of endogenous estrogens by blocking the hormone receptors are discussed as modes of action of I and II.
|Additional information (public):||CAN 96:28366 1-6 Pharmacology 15663-27-1; 60426-60-0 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by, mechanism of)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Receptors Role: BIOL (Biological study) (for estrogens, cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum inhibition of estrogens interaction with, neoplasm inhibition mechanism in relation to) Estrogens Role: BIOL (Biological study) (receptors for, cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum interaction with, neoplasm inhibition mechanism in relation to) Neoplasm inhibitors (cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum as) Deoxyribonucleic acid formation (cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum inhibition of, neoplasm inhibition mechanism in relation to) cis platinum antitumor mechanism|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 09:31|
|Last Modified:||12 Nov 2010 09:31|