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Studies on the mammary tumor inhibiting effect of cis-bis(glycylglycin ethyl ester)platinum(II) chloride

Seidenberger, Horst and Kranzfelder, Gerhard and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth, Michael (1981) Studies on the mammary tumor inhibiting effect of cis-bis(glycylglycin ethyl ester)platinum(II) chloride. Archiv der Pharmazie 314 (11), pp. 955-967.

Full text not available from this repository.

Abstract

In vivo, cis-dichlorodiammineplatinum(II) (I) [15663-27-1] and cis-dichlorobis(glycylglycine Et ester)platinum(II) (II) [60426-60-0] inhibited the DMBA-induced hormone-dependent mammary carcinoma of the SD rat. In vitro, a marked effect on DNA synthesis by mammary tumor cells and an inhibition of estradiol-receptor interaction by I and II were demonstrated. Binding to DNA and inhibition of the proliferation-stimulating effect of endogenous estrogens by blocking the hormone receptors are discussed as modes of action of I and II.

Item Type:

Article

Additional information (public):

CAN 96:28366 1-6 Pharmacology 15663-27-1; 60426-60-0 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by, mechanism of)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

Projects:

SFB 234

Identification Number:

Value	Type
1982:28366	Other

Keywords:

Receptors Role: BIOL (Biological study) (for estrogens, cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum inhibition of estrogens interaction with, neoplasm inhibition mechanism in relation to) Estrogens Role: BIOL (Biological study) (receptors for, cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum interaction with, neoplasm inhibition mechanism in relation to) Neoplasm inhibitors (cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum as) Deoxyribonucleic acid formation (cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum inhibition of, neoplasm inhibition mechanism in relation to) cis platinum antitumor mechanism

Subjects:

500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Yes

Owner:

Petra Gürster

Deposited On:

12 Nov 2010 10:31