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Metal complexes with biologically important ligands. XXI. Antitumor active cis-platinum(II) complexes with alpha -amino acid esters and peptide esters. Structure of cis-dichlorobis(glycylglycine ethyl ester)platinum(II)

Beck, Wolfgang and Bissinger, Herbert and Girnth-Weller, Michael and Purucker, Bernhard and Thiel, Gerhard and Zippel, Horst and Seidenberger, Horst and Wappes, Beate and Schönenberger, Helmut (1982) Metal complexes with biologically important ligands. XXI. Antitumor active cis-platinum(II) complexes with alpha -amino acid esters and peptide esters. Structure of cis-dichlorobis(glycylglycine ethyl ester)platinum(II). Chemische Berichte 115 (6), pp. 2256-2270.

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Abstract

cis-PtX2L2 (X = Cl, Br, I; L = alpha -amino acid ester, peptide ester) and cis-PtZL2 (H2Z = oxalic acid, malonic acid) were prepd. from PtX42- or PtZ22- and L. The dipeptide complexes were also prepd. via peptide synthesis from PtCl2(NH2CHRCO2H)2 and alpha -amino acid esters using carbodiimide as the coupling agent. PtCl2L2 (L = alpha -amino acid ester) were prepd. from cis-Pt(NH2CHRCO)2 and alc. ...

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Item Type:Article
Date:1982
Additional information (public):CAN 97:155280 78-7 Inorganic Chemicals and Reactions 60426-60-0P Role: PRP (Properties), SPN (Synthetic preparation), PREP (Preparation) (prepn. and crystal structure of); 60399-28-2P; 82474-52-0P; 82474-53-1P; 82474-54-2P; 82474-55-3P; 82474-56-4P; 82474-57-5P; 82474-58-6P; 82474-59-7P; 82474-60-0P; 82474-61-1P; 82474-62-2P; 82474-63-3P; 82474-64-4P; 82482-19-7P; 82484-32-0P; 82484-33-1P; 82484-34-2P; 82510-10-9P; 82510-11-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 60426-61-1 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with amino acid Et ester); 17567-45-2 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with amino acid Et esters); 30729-26-1 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with ethanol); 64-17-5 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with cis-bis(alpha -amino acid)platinum); 627-74-7; 4117-31-1 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with cis-dichlorobis(p-nitrophenyl glycinate)platinum)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1982:555280Other
Keywords:structure platinum ethyl glycylglycinate chloro platinum peptide amino acid ester
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 09:30
Last Modified:12 Nov 2010 09:30
Item ID:17632
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