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Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

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Abstract

trans-[3,3'-] [84609-01-8] And trans-[4,4'-(1,2-diethyl-1,2-cyclopropanediyl)-bis-(phenyl)] diacetate (I) [84608-97-9] and their 3,3-dichloro derivs. were prepd., and their effect on postmenopausal, hormone-dependent human mammary carcinoma and estrogen receptor affinities in calf uterus cytosol were detd. Meta-substituted compds. exhibited a lower receptor affinity than their para-substituted ...

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Item Type:Article
Date:1982
Additional information (public):CAN 98:119150 1-3 Pharmacology 84609-02-9; 84609-03-0 Role: PROC (Process) (estrogen receptor binding of); 57660-12-5P; 84608-99-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and acetoxylation and methoxylation of); 57660-16-9P; 84609-00-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and acetylation of); 588-59-0DP Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and antitumor activity and estrogen receptor binding of); 84608-97-9P; 84609-01-8P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of); 5965-06-0P; 57660-13-6P; 70424-18-9P; 84608-98-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and estrogen receptor binding of); 130-79-0; 76473-06-8 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with benzylammonium chloride); 3287-99-8 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with dimethoxydiethylstilbenes); 26264-09-5 Role: BIOL (Biological study) (reaction with diethylvinylene-bis(phenyl)diacetate)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1983:119150Other
Keywords:Uterus (estrogen receptors of, stilbene derivs. binding by, antitumor activity in relation to) Receptors Role: BIOL (Biological study) (for estrogens, of uterus, stilbene derivs. binding by, antitumor activity in relation to) Estrogens Role: BIOL (Biological study) (receptors for, of uterus, stilbene derivs. binding by, antitumor activity in relation to) Neoplasm inhibitors (carcinoma, mammary, stilbene derivs. as, in human) Cytoplasm (cytosol, estrogen receptors of, of uterus, stilbene derivs. binding by, antitumor activity in relation to) Molecular structure-biological activity relationship (estrogen receptor-binding, of stilbene derivs.) Mammary gland (neoplasm, carcinoma, (diethylcyclopropanediyl)bis(phenyl) diacetates for treatment of human) ethylcyclopropanediylbisphenyl diacetate antitumor stilbene analog mammary carcinoma estrogen receptor stilbene analog
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 09:26
Last Modified:12 Nov 2010 09:26
Item ID:17634
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