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Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates

Schneider, Martin R. und Schönenberger, Helmut und Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), S. 491-495.

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Zusammenfassung

trans-[3,3'-] [84609-01-8] And trans-[4,4'-(1,2-diethyl-1,2-cyclopropanediyl)-bis-(phenyl)] diacetate (I) [84608-97-9] and their 3,3-dichloro derivs. were prepd., and their effect on postmenopausal, hormone-dependent human mammary carcinoma and estrogen receptor affinities in calf uterus cytosol were detd. Meta-substituted compds. exhibited a lower receptor affinity than their para-substituted ...

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Dokumentenart:Artikel
Datum:1982
Zusätzliche Informationen (Öffentlich):CAN 98:119150 1-3 Pharmacology 84609-02-9; 84609-03-0 Role: PROC (Process) (estrogen receptor binding of); 57660-12-5P; 84608-99-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and acetoxylation and methoxylation of); 57660-16-9P; 84609-00-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and acetylation of); 588-59-0DP Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and antitumor activity and estrogen receptor binding of); 84608-97-9P; 84609-01-8P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of); 5965-06-0P; 57660-13-6P; 70424-18-9P; 84608-98-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and estrogen receptor binding of); 130-79-0; 76473-06-8 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with benzylammonium chloride); 3287-99-8 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with dimethoxydiethylstilbenes); 26264-09-5 Role: BIOL (Biological study) (reaction with diethylvinylene-bis(phenyl)diacetate)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger
Projekte:SFB 234
Identifikationsnummer:
WertTyp
1983:119150Andere
Stichwörter / Keywords:Uterus (estrogen receptors of, stilbene derivs. binding by, antitumor activity in relation to) Receptors Role: BIOL (Biological study) (for estrogens, of uterus, stilbene derivs. binding by, antitumor activity in relation to) Estrogens Role: BIOL (Biological study) (receptors for, of uterus, stilbene derivs. binding by, antitumor activity in relation to) Neoplasm inhibitors (carcinoma, mammary, stilbene derivs. as, in human) Cytoplasm (cytosol, estrogen receptors of, of uterus, stilbene derivs. binding by, antitumor activity in relation to) Molecular structure-biological activity relationship (estrogen receptor-binding, of stilbene derivs.) Mammary gland (neoplasm, carcinoma, (diethylcyclopropanediyl)bis(phenyl) diacetates for treatment of human) ethylcyclopropanediylbisphenyl diacetate antitumor stilbene analog mammary carcinoma estrogen receptor stilbene analog
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:12 Nov 2010 09:26
Zuletzt geändert:12 Nov 2010 09:26
Dokumenten-ID:17634
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