Schneider, M. R. and Schönenberger, Helmut and Michel, R. T. and Fortmeyer, H. P. (1982) Synthesis and evaluation of catechol analogs of diethylstilbestrol on a hormone-dependent human mammary carcinoma implanted in nude mice. Journal of cancer research and clinical oncology 104 (3), pp. 219-227.
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E-3,4-bis(3',4'-diacetoxyphenyl)hex-3-ene (I) [84675-77-4], E-4(4'-acetoxyphenyl)-3(3',4'-diacetoxyphenyl)hex-3-ene (II) [84675-78-5], and E-4(3'-acetoxyphenyl)-3(3',4'-diacetoxyphenyl)hex-3-ene (III) [84675-79-6] were synthesized by known methods and were tested for biol. effects with respect to their estradiol receptor affinity, uterotropic and antiuterotropic properties, and antitumor ...
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|Additional Information (public):||CAN 98:119855 2-4 Mammalian Hormones 91-16-7 Role: RCT (Reactant), RACT (Reactant or reagent) (acylation of); 4927-54-2P; 4927-55-3P; 84675-71-8P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and alkylation of); 56-53-1DP; 84675-77-4P; 84675-78-5P; 84675-79-6P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and biol. activity of); 75513-68-7P; 84675-75-2P; 84675-76-3P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and ether cleavage and acetylation of); 84675-72-9P; 84675-73-0P; 84675-74-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction with Et magnesium bromide and dehydration of); 50-28-2 Role: BIOL (Biological study) (receptor binding of, DES catechol analogs interaction in)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger|
|Keywords:||Neoplasm inhibitors (DES catechol analogs) Uterus (DES catechol analogs effect on growth of) Receptors Role: BIOL (Biological study) (estradiol binding by, DES catechol analog interaction in) Carcinoma (of mammary gland, DES catechol analogs inhibition of) Mammary gland (neoplasm, carcinoma, DES catechol analogs inhibition of) DES catechol analog prepn estrogen carcinoma mammary inhibition DES analog uterus growth DES catechol analog|
|Dewey Decimal Classification:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 09:21|
|Last Modified:||12 Nov 2010 09:21|