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Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols

Hartmann, Rolf W. und Schwarz, Walter und Schönenberger, Helmut (1983) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols. Journal of medicinal chemistry 26 (8), S. 1137-1144.

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Zusammenfassung

The syntheses of sym. 3,3'- and 2,2'-disubstituted meso hexestrol derivs. (I) are described (3,3'-R = : OH (II) [79199-51-2], F (III) [74536-61-1], Cl (IV) [79140-57-1], Br [74536-64-4], I [55508-15-1], CH2NMe2 [85720-37-2], Me [10465-10-8], CH2OMe [85720-38-3], CH2OEt [85720-40-7], CH2OH [85720-41-8], NO2 [66877-40-5], NH2 [66877-41-6], NMe2 [85720-42-9], Ac [85720-43-0], and Et [85720-45-2]; ...

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Dokumentenart:Artikel
Datum:1983
Zusätzliche Informationen (Öffentlich):CAN 99:33234 2-2 Mammalian Hormones 28231-25-6 Role: RCT (Reactant), RACT (Reactant or reagent) (acetylation of); 84-16-2D Role: BIOL (Biological study) (estrogen receptor-binding activity of, structure in relation to); 85720-39-4P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and alk. sapon. of); 10465-10-8P; 55508-15-1P; 66877-40-5P; 66877-41-6P; 74536-61-1P; 74536-64-4P; 79140-57-1P; 79199-51-2P; 85720-37-2P; 85720-38-3P; 85720-40-7P; 85720-41-8P; 85720-42-9P; 85720-43-0P; 85720-45-2P; 85720-47-4P; 85720-49-6P; 85720-52-1P; 85720-55-4P; 85720-57-6P; 85720-58-7P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and estrogen receptor-binding activity of); 74536-60-0P; 79140-65-1P; 85720-33-8P; 85720-44-1P; 85720-46-3P; 85720-48-5P; 85720-50-9P; 85720-53-2P; 85720-56-5P; 85720-59-8P; 85735-20-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and ether cleavage of); 85720-34-9P; 85720-35-0P; 85720-36-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and hydrogenation of); 85720-54-3P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of); 830-99-9P; 23600-60-4P; 53773-75-4P; 85720-51-0P; 85720-60-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reductive coupling of); 586-22-1; 1835-04-7; 4394-54-1; 13329-61-8 Role: RCT (Reactant), RACT (Reactant or reagent) (reductive coupling of)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger
Projekte:SFB 234
Identifikationsnummer:
WertTyp
1983:433234Andere
Stichwörter / Keywords:Receptors Role: BIOL (Biological study) (for estrogen, hexestrol deriv. binding by) Estrogens Role: BIOL (Biological study) (receptor for, hexestrol deriv. binding by) Molecular structure-biological activity relationship (estrogen receptor-binding, of hexestrol derivs.) hydroxyphenylethane prepn estrogen receptor binding hexestrol deriv estrogen receptor binding structure activity hexestrol deriv
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:12 Nov 2010 09:11
Zuletzt geändert:12 Nov 2010 09:11
Dokumenten-ID:17639
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