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Mechanism of action of cis-bis(glycylglycineethyl ester)platinum(II) chloride - effect on protein biosynthesis

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael (1983) Mechanism of action of cis-bis(glycylglycineethyl ester)platinum(II) chloride - effect on protein biosynthesis. Archiv der Pharmazie 316 (12), pp. 1007-1012.

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Abstract

The effect of cis-bis(glycylglycine Et ester)platinum(II) chloride [60426-60-0] and cisplatinum [15663-27-1] on the protein biosynthesis of Walker-25 carcinosarcoma was confirmed to arise from an inhibition of the aminoacylation of tRNA and the biosynthesis of polyphenylalanine. Expts. were conducted in a cell-free system using poly-U as exogenous ...

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Item Type:Article
Date:1983
Additional information (public):CAN 100:29396 1-6 Pharmacology 15663-27-1; 60426-60-0 Role: BIOL (Biological study) (protein formation inhibition by, neoplasm inhibition in relation to)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1984:29396Other
Keywords:Ribonucleic acids Role: RCT (Reactant), RACT (Reactant or reagent) (aminoacylation of, antitumor platinum compds. effect on, neoplasm inhibition in relation to) Protein formation (antitumor platinum compds. effect on, neoplasm inhibition in relation to) Neoplasm inhibitors (platinum compds., protein formation inhibition as mechanism of action of) protein formation antitumor platinum
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 09:09
Last Modified:12 Nov 2010 09:09
Item ID:17641
Owner Only: item control page
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