Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael (1983) Mechanism of action of cis-bis(glycylglycineethyl ester)platinum(II) chloride - effect on protein biosynthesis. Archiv der Pharmazie 316 (12), pp. 1007-1012.
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The effect of cis-bis(glycylglycine Et ester)platinum(II) chloride [60426-60-0] and cisplatinum [15663-27-1] on the protein biosynthesis of Walker-25 carcinosarcoma was confirmed to arise from an inhibition of the aminoacylation of tRNA and the biosynthesis of polyphenylalanine. Expts. were conducted in a cell-free system using poly-U as exogenous messenger.
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|Additional Information (public):||CAN 100:29396 1-6 Pharmacology 15663-27-1; 60426-60-0 Role: BIOL (Biological study) (protein formation inhibition by, neoplasm inhibition in relation to)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Ribonucleic acids Role: RCT (Reactant), RACT (Reactant or reagent) (aminoacylation of, antitumor platinum compds. effect on, neoplasm inhibition in relation to) Protein formation (antitumor platinum compds. effect on, neoplasm inhibition in relation to) Neoplasm inhibitors (platinum compds., protein formation inhibition as mechanism of action of) protein formation antitumor platinum|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 09:09|
|Last Modified:||12 Nov 2010 09:09|