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Mechanism of action of cis-bis(glycylglycineethyl ester)platinum(II) chloride - effect on protein biosynthesis

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael (1983) Mechanism of action of cis-bis(glycylglycineethyl ester)platinum(II) chloride - effect on protein biosynthesis. Archiv der Pharmazie 316 (12), pp. 1007-1012.

Full text not available from this repository.

Abstract

The effect of cis-bis(glycylglycine Et ester)platinum(II) chloride [60426-60-0] and cisplatinum [15663-27-1] on the protein biosynthesis of Walker-25 carcinosarcoma was confirmed to arise from an inhibition of the aminoacylation of tRNA and the biosynthesis of polyphenylalanine. Expts. were conducted in a cell-free system using poly-U as exogenous messenger.

Item Type:

Article

Additional information (public):

CAN 100:29396 1-6 Pharmacology 15663-27-1; 60426-60-0 Role: BIOL (Biological study) (protein formation inhibition by, neoplasm inhibition in relation to)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

Projects:

SFB 234

Identification Number:

Value	Type
1984:29396	Other

Keywords:

Ribonucleic acids Role: RCT (Reactant), RACT (Reactant or reagent) (aminoacylation of, antitumor platinum compds. effect on, neoplasm inhibition in relation to) Protein formation (antitumor platinum compds. effect on, neoplasm inhibition in relation to) Neoplasm inhibitors (platinum compds., protein formation inhibition as mechanism of action of) protein formation antitumor platinum

Subjects:

500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Yes

Owner:

Petra Gürster

Deposited On:

12 Nov 2010 10:09