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Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.

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Abstract

cis-bis(glycylglycinethylester)platinum II chloride (I) [60426-60-0] interfered with the nucleic acid metab. in tumor cells by inhibiting the DNA template activity as well as the DNA- [9012-90-2] and RNA polymerase [9014-24-8] and the ribonucleotide reductase [9040-57-7] system. The activity of I was similar to the therapeutically used Pt coordination complex cis-Pt(NH3)2Cl2.


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Item Type:Article
Date:1983
Additional Information (public):CAN 98:119309 1-6 Pharmacology 9012-90-2; 9014-24-8; 9040-57-7 Role: BIOL (Biological study) (inhibition of, nucleic acid metab. inhibition by platinum complex in tumor in relation to); 60426-60-0 Role: BIOL (Biological study) (nucleic acid metab. in tumor response to, mechanism in relation to)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1983:119309Other
Keywords:Neoplasm inhibitors (glycylglycine Et ester platinum complex) Deoxyribonucleic acid formation Ribonucleic acid formation (glycylglycine Et ester platinum complex inhibition of, antitumor mechanism in relation to) Nucleic acids Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (metab. of, by tumor, platinum complex inhibition of, antitumor mechanism in relation to) Deoxyribonucleic acids Role: BIOL (Biological study) (template activity of, glycylglycine Et ester platinum complex effect on, antitumor activity in relation to) platinum complex nucleic acid metab antitumor platinum complex nucleic acid
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:12 Nov 2010 09:07
Last Modified:12 Nov 2010 09:07
Item ID:17642
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