Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.
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cis-bis(glycylglycinethylester)platinum II chloride (I) [60426-60-0] interfered with the nucleic acid metab. in tumor cells by inhibiting the DNA template activity as well as the DNA- [9012-90-2] and RNA polymerase [9014-24-8] and the ribonucleotide reductase [9040-57-7] system. The activity of I was similar to the therapeutically used Pt coordination complex cis-Pt(NH3)2Cl2.
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|Additional Information (public):||CAN 98:119309 1-6 Pharmacology 9012-90-2; 9014-24-8; 9040-57-7 Role: BIOL (Biological study) (inhibition of, nucleic acid metab. inhibition by platinum complex in tumor in relation to); 60426-60-0 Role: BIOL (Biological study) (nucleic acid metab. in tumor response to, mechanism in relation to)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Neoplasm inhibitors (glycylglycine Et ester platinum complex) Deoxyribonucleic acid formation Ribonucleic acid formation (glycylglycine Et ester platinum complex inhibition of, antitumor mechanism in relation to) Nucleic acids Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (metab. of, by tumor, platinum complex inhibition of, antitumor mechanism in relation to) Deoxyribonucleic acids Role: BIOL (Biological study) (template activity of, glycylglycine Et ester platinum complex effect on, antitumor activity in relation to) platinum complex nucleic acid metab antitumor platinum complex nucleic acid|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 09:07|
|Last Modified:||12 Nov 2010 09:07|