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Relations between structure and antitumor activity of cis-dichloro[bis(oligopeptide ester)platinum(II)] complexes

Seidenberger, Horst and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Ruckdeschel, Gotthart (1983) Relations between structure and antitumor activity of cis-dichloro[bis(oligopeptide ester)platinum(II)] complexes. Archiv der Pharmazie 316 (2), pp. 121-131.

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Abstract

Several title compds., cis- and trans-[PtA2X2] complexes (A = esters of oligopeptides; X = Cl, oxalate, or malonate), were tested for their ability to inhibit thymidine 3H incorporation by suspensions by ADJ/PC6 plasmacytoma cells, as an index of antitumor action. The effect was markedly dependent on the type, no., and sequence of the amino acids in the peptide component. The most active compd. ...

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Item Type:Article
Date:1983
Additional information (public):CAN 98:137216 1-3 Pharmacology 14096-51-6; 14913-33-8; 15663-27-1; 39680-31-4; 60399-28-2; 60426-60-0; 82474-57-5; 82474-58-6; 82474-59-7; 82474-60-0; 82474-61-1; 82474-62-2; 82474-63-3; 82482-19-7; 82484-32-0; 82484-33-1; 85166-35-4; 85166-36-5; 85200-51-7 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by, structure in relation to); 7440-06-4DP; 25104-18-1DP; 38000-06-5DP Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of and neoplasm inhibition by, structure in relation to); 25104-18-1 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with dipotassium platinum tetrachloride); 10025-99-7 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with polylysine)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1983:137216Other
Keywords:Deoxyribonucleic acid formation (by neoplasm, platinum-peptide ester complexes inhibition of, neoplasm inhibition in relation to) Deoxyribonucleic acids Role: PRP (Properties) (interaction of, with platinum-peptide ester complexes, neoplasm inhibition in relation to) Neoplasm inhibitors (platinum-peptide ester complexes) Molecular structure-biological activity relationship (neoplasm-inhibiting, of platinum-peptide ester complexes) antitumor platinum peptide complex structure antitumor activity platinum complex
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 09:06
Last Modified:12 Nov 2010 09:06
Item ID:17643
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