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Antitumor activity of cis-dichlorobis(alpha -amino acid ester)platinum complexes

Wappes, Beate and Schönenberger, Helmut and Bissinger, Herbert and Beck, Wolfgang (1983) Antitumor activity of cis-dichlorobis(alpha -amino acid ester)platinum complexes. Archiv der Pharmazie 316 (10), pp. 854-862.

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cis-PtCl2(AS)2complexes (AS = amino acid or its ester) were tested using the mammary tumor cell line MDA-MB 231 and a cell suspension of the ADJ/PC6 plasmacytoma. Only the esters cis-PtCl2(GlyOBu)2 [82474-53-1] and cis-PtCl2(GlyO-tert-Bu)2 (I) [82474-54-2] inhibited the incorporation of [3H]thymidine, whereas the free acids were ineffective. In contrast to the results of the in vitro assays, I did not influence tumor growth of the ADJ/PC6 plasmacytoma in vivo.

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Item type:Article
Additional Information (public):CAN 99:205731 1-6 Pharmacology 17567-45-2; 38780-36-8; 82474-52-0; 82474-53-1; 82474-54-2; 82474-56-4; 86293-63-2; 87824-87-1; 87824-88-2 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm-inhibiting activity of); 82474-55-3P; 87824-86-0P; 87824-89-3P; 87824-90-6P; 87860-83-1P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and neoplasm-inhibiting activity of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
Keywords:Neoplasm inhibitors (cis-dichlorobis(alpha -amino acid ester) platinum complexes) amino acid platinum antitumor
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited on:12 Nov 2010 09:05
Last modified:12 Nov 2010 09:05
Item ID:17644
Owner only: item control page
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