Schönenberger, Helmut and Wappes, Beate and Jennerwein, Margaretha and Berger, Martin (1984) Development of selectively acting platinum complexes. Cancer treatment reviews 11 (Suppl. A), pp. 125-130.
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The antitumor activity of the stereoisomers of dichloro-1,2-bis(4-hydroxyphenyl)ethylenediamineplatinum (I) was studied in vitro (on ADJ/PC6 plasmacytoma and MDA breast cancer cells) as well as in vivo (in mice bearing ADJ/PC6 plasmacytoma). Whereas (-)-I [91326-62-4] was highly active both in vivo and in vitro, the other isomers were less active; the meso isomer [91265-66-6] was more or less ...
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|Additional Information (public):||CAN 104:215 1-3 Pharmacology 91265-66-6; 91326-62-4; 91326-63-5 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (neoplasm-inhibitory activity of); 91326-61-3 Role: BIOL (Biological study) (neoplasm-inhibitory activity of racemic)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Neoplasm inhibitors (dichlorobis(hydroxyphenyl)ethylenediamineplatinum isomers, structure in relation to) Molecular structure-biological activity relationship (neoplasm-inhibiting, of dichlorobis(hydroxyphenyl)ethylenediamineplatinum isomers) ethylenediamineplatinum antitumor structure activity platinum complex antitumor structure activity|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 08:59|
|Last Modified:||12 Nov 2010 08:59|