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Development of selectively acting platinum complexes

Schönenberger, Helmut and Wappes, Beate and Jennerwein, Margaretha and Berger, Martin (1984) Development of selectively acting platinum complexes. Cancer treatment reviews 11 (Suppl. A), pp. 125-130.

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The antitumor activity of the stereoisomers of dichloro-1,2-bis(4-hydroxyphenyl)ethylenediamineplatinum (I) was studied in vitro (on ADJ/PC6 plasmacytoma and MDA breast cancer cells) as well as in vivo (in mice bearing ADJ/PC6 plasmacytoma). Whereas (-)-I [91326-62-4] was highly active both in vivo and in vitro, the other isomers were less active; the meso isomer [91265-66-6] was more or less ...


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Item Type:Article
Additional Information (public):CAN 104:215 1-3 Pharmacology 91265-66-6; 91326-62-4; 91326-63-5 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (neoplasm-inhibitory activity of); 91326-61-3 Role: BIOL (Biological study) (neoplasm-inhibitory activity of racemic)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
Keywords:Neoplasm inhibitors (dichlorobis(hydroxyphenyl)ethylenediamineplatinum isomers, structure in relation to) Molecular structure-biological activity relationship (neoplasm-inhibiting, of dichlorobis(hydroxyphenyl)ethylenediamineplatinum isomers) ethylenediamineplatinum antitumor structure activity platinum complex antitumor structure activity
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:12 Nov 2010 08:59
Last Modified:12 Nov 2010 08:59
Item ID:17648
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