Deutsch
Brunner, Henri and Schmidt, Manfred and Unger, Gerfried and Schönenberger, Helmut (1985) Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids. European journal of medicinal chemistry 20 (6), pp. 509-512.
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Abstract
The title complexes I (R = CH2Ph, CHMe2, CH2CHMe2, CHMeEt, (CH2)2SMe) were prepd. from substituted L-1,2-diaminoethanes derived from L-alpha -amino acids and tested for antitumor activity in vitro. I inhibited DNA formation in hormone independent human mammary carcinoma cell line MDA-MB 231.
| Item Type: | Article | ||||
|---|---|---|---|---|---|
| Additional information (public): | CAN 104:199664 1-6 Pharmacology 61-90-5; 63-68-3; 63-91-2; 72-18-4; 73-32-5 Role: RCT (Reactant), RACT (Reactant or reagent) (esterification of); 2577-46-0P; 2577-90-4P; 2666-93-5P; 4070-48-8P; 10332-17-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and amidation of); 15967-74-5P; 40630-14-6P; 68013-51-4P; 85612-60-8P; 101996-49-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and complexation with platinum of); 107-15-3DP; 7440-06-4DP; 102033-02-3P; 102033-03-4P; 102033-04-5P; 102033-05-6P; 102050-52-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and human mammary carcinoma inhibition by); 687-51-4P; 4510-08-1P; 4540-60-7P; 5241-58-7P; 14445-54-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger | ||||
| Projects: | SFB 234 | ||||
| Identification Number: |
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| Keywords: | Deoxyribonucleic acid formation (inhibition of, of human mammary carcinoma, by platinum complexes of diaminoethanes) Neoplasm inhibitors (carcinoma, platinum complexes of diaminoethanes as, in human mammary gland) Mammary gland (neoplasm, carcinoma, treatment of, with platinum complexes of diaminoethanes, in human) aminoethane platinum complex prepn antitumor | ||||
| Subjects: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Owner: | Petra Gürster | ||||
| Deposited On: | 12 Nov 2010 09:54 | ||||
| Last Modified: | 12 Nov 2010 09:54 | ||||
| Item ID: | 17651 |
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