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Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids

Brunner, Henri and Schmidt, Manfred and Unger, Gerfried and Schönenberger, Helmut (1985) Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids. European journal of medicinal chemistry 20 (6), pp. 509-512.

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Abstract

The title complexes I (R = CH2Ph, CHMe2, CH2CHMe2, CHMeEt, (CH2)2SMe) were prepd. from substituted L-1,2-diaminoethanes derived from L-alpha -amino acids and tested for antitumor activity in vitro. I inhibited DNA formation in hormone independent human mammary carcinoma cell line MDA-MB ...

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Item Type:Article
Date:1985
Additional information (public):CAN 104:199664 1-6 Pharmacology 61-90-5; 63-68-3; 63-91-2; 72-18-4; 73-32-5 Role: RCT (Reactant), RACT (Reactant or reagent) (esterification of); 2577-46-0P; 2577-90-4P; 2666-93-5P; 4070-48-8P; 10332-17-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and amidation of); 15967-74-5P; 40630-14-6P; 68013-51-4P; 85612-60-8P; 101996-49-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and complexation with platinum of); 107-15-3DP; 7440-06-4DP; 102033-02-3P; 102033-03-4P; 102033-04-5P; 102033-05-6P; 102050-52-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and human mammary carcinoma inhibition by); 687-51-4P; 4510-08-1P; 4540-60-7P; 5241-58-7P; 14445-54-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1986:199664Other
Keywords:Deoxyribonucleic acid formation (inhibition of, of human mammary carcinoma, by platinum complexes of diaminoethanes) Neoplasm inhibitors (carcinoma, platinum complexes of diaminoethanes as, in human mammary gland) Mammary gland (neoplasm, carcinoma, treatment of, with platinum complexes of diaminoethanes, in human) aminoethane platinum complex prepn antitumor
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 08:54
Last Modified:12 Nov 2010 08:54
Item ID:17651
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