Engel, J. and Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.
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Studies on structure-activity relationships of organometallic anticancer drugs are reviewed. Three methods for the development of new structures are described. Drug targeting: platinum complexes with oestrophilic ligands were synthesized, and the endocrine and cytostatic effects are discussed. Quantitative structure-activity relationship determination is presented as a rational method for the design of active compounds. The molecular modelling technique is used for the analysis of molecular properties.
|Additional information (public):||France|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Animals *Antineoplastic Agents Cell Division: DE, drug effects Cell Line Leukemia L1210: DT, drug therapy Mammary Neoplasms, Experimental: DT, drug therapy Mice *Neoplasms, Experimental: DT, drug therapy *Organometallic Compounds: TU, therapeutic use Receptors, Estrogen: ME, metabolism Structure-Activity Relationship 0 (Antineoplastic Agents) 0 (Organometallic Compounds) 0 (Receptors, Estrogen)|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 09:35|
|Last Modified:||12 Nov 2010 09:35|
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