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Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes

Hartmann, Rolf W. and Heindl, Alexander and Schneider, Martin R. and Schönenberger, Helmut (1986) Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes. Journal of medicinal chemistry 29 (3), pp. 322-328.

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Abstract

trans-Bis(trifluoromethyl)ethenes I (R = 3-HO, 4-HO) were prepd. by reductive coupling (TiCl4/Zn/pyridine) of the methoxy-substituted alpha ,alpha ,alpha -trifluoroacetophenones, sepn. of the resulting cis- and trans-stilbene derivs., and ether cleavage with BBr3. The cis-stilbenes were catalytically hydrogenated to give meso-hexafluoro-2,3-bis(hydroxyphenyl)butanes II (R = 3-HO, 4-HO). I and II ...

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Item Type:Article
Date:1986
Additional information (public):CAN 104:109110 25-3 Benzene, Its Derivatives, and Condensed Benzenoid Compounds 2962-14-3; 74944-95-9; 78682-42-5 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (estrogenic and antitumor activity of); 28714-18-3P; 99749-11-8P; 99749-13-0P; 99749-14-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and demethylation of); 28714-19-4P; 99749-15-2P; 99749-16-3P; 99749-17-4P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and estrogenic and antitumor activity of); 28714-28-5P; 99749-12-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and hydrogenation of); 711-38-6P; 30724-22-2P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reductive coupling of); 76-05-1 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with (methoxyphenyl)magnesium bromides); 13139-86-1; 36282-40-3 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with trifluoroacetic acid)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1986:109110Other
Keywords:Neoplasm inhibitors (hexafluorobis(hydroxyphenyl)butanes and -butenes, for mammary tumors) Estrogens Role: RCT (Reactant), RACT (Reactant or reagent) (receptor for, of mammary tumors, inhibition by hexafluorobis(hydroxyphenyl)butanes and -butenes) fluorinated bishydroxyphenylbutane antitumor hexafluorobishydroxyphenylbutane bishydroxyphenylbutane estrogenic hexafluorobishydroxyphenylbutane bishydroxyphenylbutane phenol hexafluorobutanediyl prepn antitumor
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 08:33
Last Modified:12 Nov 2010 08:33
Item ID:17658
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