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Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes

Hartmann, Rolf W. und Heindl, Alexander und Schneider, Martin R. und Schönenberger, Helmut (1986) Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes. Journal of medicinal chemistry 29 (3), S. 322-328.

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Zusammenfassung

trans-Bis(trifluoromethyl)ethenes I (R = 3-HO, 4-HO) were prepd. by reductive coupling (TiCl4/Zn/pyridine) of the methoxy-substituted alpha ,alpha ,alpha -trifluoroacetophenones, sepn. of the resulting cis- and trans-stilbene derivs., and ether cleavage with BBr3. The cis-stilbenes were catalytically hydrogenated to give meso-hexafluoro-2,3-bis(hydroxyphenyl)butanes II (R = 3-HO, 4-HO). I and II ...

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Dokumentenart:Artikel
Datum:1986
Zusätzliche Informationen (Öffentlich):CAN 104:109110 25-3 Benzene, Its Derivatives, and Condensed Benzenoid Compounds 2962-14-3; 74944-95-9; 78682-42-5 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (estrogenic and antitumor activity of); 28714-18-3P; 99749-11-8P; 99749-13-0P; 99749-14-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and demethylation of); 28714-19-4P; 99749-15-2P; 99749-16-3P; 99749-17-4P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and estrogenic and antitumor activity of); 28714-28-5P; 99749-12-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and hydrogenation of); 711-38-6P; 30724-22-2P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reductive coupling of); 76-05-1 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with (methoxyphenyl)magnesium bromides); 13139-86-1; 36282-40-3 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with trifluoroacetic acid)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger
Projekte:SFB 234
Identifikationsnummer:
WertTyp
1986:109110Andere
Stichwörter / Keywords:Neoplasm inhibitors (hexafluorobis(hydroxyphenyl)butanes and -butenes, for mammary tumors) Estrogens Role: RCT (Reactant), RACT (Reactant or reagent) (receptor for, of mammary tumors, inhibition by hexafluorobis(hydroxyphenyl)butanes and -butenes) fluorinated bishydroxyphenylbutane antitumor hexafluorobishydroxyphenylbutane bishydroxyphenylbutane estrogenic hexafluorobishydroxyphenylbutane bishydroxyphenylbutane phenol hexafluorobutanediyl prepn antitumor
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:12 Nov 2010 08:33
Zuletzt geändert:12 Nov 2010 08:33
Dokumenten-ID:17658
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