Amselgruber, W. and Sinowatz, F. and Spruss, Thilo and Schneider, M. R. and Karl, J. and Schönenberger, Helmut (1987) Effect of estrophilic platinum complex on the mouse uterus. Virchows Archiv: B 53 (4), pp. 198-207.
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The effects of a newly synthesized estrogen-receptor affine platinum complex [dichloro-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine-platinum(II), mesoconfiguration] on the mouse uterus were studied using light and electron-microscopy. The results were compared with Tamoxifen, cisplatin and the estrophilic ligand [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine-dihydrochloride, mesoconfiguration]. Both estrophilic ligand and estrophilic platinum complex produced strong estrogenic effects as well as features characteristic of the uterine epithelial cell in the luteal phase of the cycle, corresponding to a massive stimulation of the surface and glandular epithelial cells. The appearance of inter- and intracellular lumina and the activation of smooth muscle cells represent further characteristic effects of the estrophilic ligand and estrophilic platinum complex.
|Additional information (public):||CAN 108:31413 1-6 Pharmacology 82772-92-7; 112149-88-9 Role: BIOL (Biological study) (uterus morphol. response to, antitumor activity in relation to)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Neoplasm inhibitors (estrophilic platinum complex as, normal uterine morphol. response to) Uterus (estrophilic platinum complex effect on morphol. of, antitumor activity in relation to) Receptors Role: BIOL (Biological study) (for estrogens, in estrophilic platinum complex effect on uterine morphol.) Estrogens Role: BIOL (Biological study) (receptors for, in estrophilic platinum complex effect on uterine morphol.) estrophilic platinum complex uterus|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 08:31|
|Last Modified:||12 Nov 2010 08:31|