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Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing phosphorus-32 as well as for the estimation of molybdenum-99 and gold-199

Trebert-Haeberlin, S. und Lux, F. und Karl, J. und Spruss, Thilo und Schönenberger, Helmut (1987) Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing phosphorus-32 as well as for the estimation of molybdenum-99 and gold-199. Journal of radioanalytical and nuclear chemistry 113 (2), S. 461-467.

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Zusammenfassung

As part of an examn. of the cytostatic effects of 1,2-diarylethylenediamine-platinum(II)-complexes the contents of Pl and biol. essential trace elements of tumor tissue and different organs were detd. by neutron activation anal. The activation anal. procedure, sepn. of 32P, and isolation of 199Au and 99Mo are described.


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Dokumentenart:Artikel
Datum:1987
Zusätzliche Informationen (Öffentlich):CAN 107:228326 1-1 Pharmacology 15663-27-1 (Cisplatin); 105856-23-3 Role: BIOL (Biological study) (detn. of platinum of, in tissues, by neutron activation anal.); 7440-06-4 (Platinum) Role: ANT (Analyte), ANST (Analytical study) (detn. of, in tissues, by neutron activation anal.); 12586-31-1 Role: BIOL (Biological study) (radiochemical analysis, neutron activation, of platinum of antitumor drugs in organs and tumor tissues); 14119-15-4 (Molybdenum-99); 14391-11-8 (Gold-199); 14596-37-3 (Phosphorus-32) Role: BIOL (Biological study) (sepn. of, in neutron activation anal. procedure for platinum detn. in tissues)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger
Projekte:SFB 234
Identifikationsnummer:
WertTyp
1987:628326Andere
Stichwörter / Keywords:Neoplasm (platinum detn. in, by neutron activation anal.) Organ (platinum of antitumor drugs detn. in, by neutron activation anal.) Radiochemical analysis (neutron activation, of platinum of antitumor drugs in organs and tumor tissues) platinum drug detn tissue neutron activation neutron activation analysis platinum drug tissue phosphorus tissue neutron activation analysis molybdenum tissue neutron activation analysis gold tissue neutron activation analysis trace element tissue neutron activation analysis
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:12 Nov 2010 08:27
Zuletzt geändert:12 Nov 2010 08:27
Dokumenten-ID:17663
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