Trebert-Haeberlin, S. and Lux, F. and Karl, J. and Spruss, Thilo and Schönenberger, Helmut (1987) Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing phosphorus-32 as well as for the estimation of molybdenum-99 and gold-199. Journal of radioanalytical and nuclear chemistry 113 (2), pp. 461-467.
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As part of an examn. of the cytostatic effects of 1,2-diarylethylenediamine-platinum(II)-complexes the contents of Pl and biol. essential trace elements of tumor tissue and different organs were detd. by neutron activation anal. The activation anal. procedure, sepn. of 32P, and isolation of 199Au and 99Mo are described.
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|Additional Information (public):||CAN 107:228326 1-1 Pharmacology 15663-27-1 (Cisplatin); 105856-23-3 Role: BIOL (Biological study) (detn. of platinum of, in tissues, by neutron activation anal.); 7440-06-4 (Platinum) Role: ANT (Analyte), ANST (Analytical study) (detn. of, in tissues, by neutron activation anal.); 12586-31-1 Role: BIOL (Biological study) (radiochemical analysis, neutron activation, of platinum of antitumor drugs in organs and tumor tissues); 14119-15-4 (Molybdenum-99); 14391-11-8 (Gold-199); 14596-37-3 (Phosphorus-32) Role: BIOL (Biological study) (sepn. of, in neutron activation anal. procedure for platinum detn. in tissues)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Neoplasm (platinum detn. in, by neutron activation anal.) Organ (platinum of antitumor drugs detn. in, by neutron activation anal.) Radiochemical analysis (neutron activation, of platinum of antitumor drugs in organs and tumor tissues) platinum drug detn tissue neutron activation neutron activation analysis platinum drug tissue phosphorus tissue neutron activation analysis molybdenum tissue neutron activation analysis gold tissue neutron activation analysis trace element tissue neutron activation analysis|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 08:27|
|Last Modified:||12 Nov 2010 08:27|