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Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing phosphorus-32 as well as for the estimation of molybdenum-99 and gold-199

Trebert-Haeberlin, S. and Lux, F. and Karl, J. and Spruss, Thilo and Schönenberger, Helmut (1987) Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing phosphorus-32 as well as for the estimation of molybdenum-99 and gold-199. Journal of radioanalytical and nuclear chemistry 113 (2), pp. 461-467.

Full text not available from this repository.

Abstract

As part of an examn. of the cytostatic effects of 1,2-diarylethylenediamine-platinum(II)-complexes the contents of Pl and biol. essential trace elements of tumor tissue and different organs were detd. by neutron activation anal. The activation anal. procedure, sepn. of 32P, and isolation of 199Au and 99Mo are described.

Item Type:

Article

Additional information (public):

CAN 107:228326 1-1 Pharmacology 15663-27-1 (Cisplatin); 105856-23-3 Role: BIOL (Biological study) (detn. of platinum of, in tissues, by neutron activation anal.); 7440-06-4 (Platinum) Role: ANT (Analyte), ANST (Analytical study) (detn. of, in tissues, by neutron activation anal.); 12586-31-1 Role: BIOL (Biological study) (radiochemical analysis, neutron activation, of platinum of antitumor drugs in organs and tumor tissues); 14119-15-4 (Molybdenum-99); 14391-11-8 (Gold-199); 14596-37-3 (Phosphorus-32) Role: BIOL (Biological study) (sepn. of, in neutron activation anal. procedure for platinum detn. in tissues)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

Projects:

SFB 234

Identification Number:

Value	Type
1987:628326	Other

Keywords:

Neoplasm (platinum detn. in, by neutron activation anal.) Organ (platinum of antitumor drugs detn. in, by neutron activation anal.) Radiochemical analysis (neutron activation, of platinum of antitumor drugs in organs and tumor tissues) platinum drug detn tissue neutron activation neutron activation analysis platinum drug tissue phosphorus tissue neutron activation analysis molybdenum tissue neutron activation analysis gold tissue neutron activation analysis trace element tissue neutron activation analysis

Subjects:

500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Yes

Owner:

Petra Gürster

Deposited On:

12 Nov 2010 09:27