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Ring-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes: compounds with a selective effect on the hormone-dependent mammary carcinoma

Karl, Johann and Gust, Ronald and Spruss, Thilo and Schneider, Martin R. and Schönenberger, Helmut and Engel, Juergen and Wrobel, Karl Heinz and Lux, Franz and Trebert-Haeberlin, Susanne (1988) Ring-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes: compounds with a selective effect on the hormone-dependent mammary carcinoma. Journal of medicinal chemistry 31 (1), pp. 72-83.

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Abstract

[1,2-Bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes with one substituent in the 2-position (Me, CF3, F, Cl, Br, I: meso- and dl-1-PtCl2, meso-(3-5)-PtCl2, meso-(7 and 8)-PtCl2) or 2 substituents in the 2,6-positions (Me, Cl: meso-2-PtCl2, meso- and dl-6-PtCl2) in both benzene rings were synthesized and tested for estrogenic and cytotoxic activities. Two complexes possessed ...

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Item Type:Article
Date:1988
Additional information (public):CAN 108:31414 1-6 Pharmacology 123-11-5 (4-Methoxybenzaldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (conversion to di-Me acetal); 83363-98-8P; 111086-47-6P; 111086-49-8P; 111086-51-2P; 111086-53-4P; 111086-56-7P; 111086-59-0P; 111086-60-3P; 111086-62-5P; 111112-51-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and demethylation of); 111086-71-6P; 111086-72-7P; 111086-73-8P; 111086-74-9P; 111086-75-0P; 111086-76-1P; 111086-77-2P; 111086-78-3P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and hydrolysis of); 7440-06-4DP (Platinum); 105855-88-7P; 105856-12-0P; 105856-14-2P; 105856-16-4P; 105856-18-6P; 105856-20-0P; 105856-21-1P; 105856-23-3P; 105928-12-9P; 105928-14-1P; 111112-53-9P; 111112-54-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and mammary carcinoma-inhibiting and estrogen receptor-binding activity of); 2186-92-7P (4-Methoxybenzaldehyde dimethyl acetal) Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and metalation and reaction with benzenesulfonyl chloride or bromine or iodine); 86111-47-9P (2,6-Dichloro-4-methoxybenzyl alcohol) Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and oxidn. of); 331-64-6P; 19447-00-8P; 43192-31-0P; 52289-54-0P; 54439-75-7P; 82772-93-8P; 105469-13-4P; 106312-36-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction with bis(hydroxyphenyl)ethylenediamine); 111086-48-7P; 111086-50-1P; 111086-52-3P; 111086-54-5P; 111086-55-6P; 111086-57-8P; 111086-58-9P; 111086-61-4P; 111086-63-6P; 111112-21-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction with dipotassium tetrachloroplatinate); 400-72-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction with formylpiperidine); 27060-75-9P (4-Bromo-3-methylanisole) Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction with magnesium and DMF); 111086-64-7P; 111086-65-8P; 111086-66-9P; 111086-67-0P; 111086-68-1P; 111086-69-2P; 111086-70-5P; 111112-52-8P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and rearrangement reaction of); 58519-80-5 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with anisic aldehydes); 30525-89-4 (Paraformaldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with dichloroanisole); 98-09-9 (Benzenesulfonyl chloride); 7553-56-2 (Iodine); 7726-95-6 (Bromine) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with methoxybenzaldehyde di-Me acetal); 33719-74-3 (3,5-Dichloroanisole) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with paraformaldehyde); 111086-79-4 Role: RCT (Reactant), RACT (Reactant or reagent) (stereoisomerization of); 100-84-5; 454-90-0; 456-49-5; 874-63-5 Role: BIOL (Biological study) (transformation to magnesium bromide and reaction with DMF)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1988:31414Other
Keywords:Neoplasm inhibitors ([bis(hydroxyphenyl)ethylenediamine]dichloroplatinum complexes, prepn. and cytotoxicity and estrogen receptor-binding activity of) Receptors Role: BIOL (Biological study) (for estrogen, [bis(hydroxyphenyl)ethylenediamine]dichloroplatinum complexes binding to) Mammary gland (neoplasm, carcinoma, estrogen-dependent, [bis(hydroxyphenyl)ethylenediamine]dichloroplatinum complexes inhibition of and estrogen receptor-binding in) hydroxyphenylethylenediamine platinum complex prepn cytotoxicity antitumor hydroxyphenylethylenediamine platinum complex estrogen receptor hydroxyphenylethylenediamine platinum complex
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 08:17
Last Modified:12 Nov 2010 08:17
Item ID:17668
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