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Antitumor activity of o-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes and their methyl ethers

Karl, Johann and Schönenberger, Helmut (1988) Antitumor activity of o-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes and their methyl ethers. Archiv der Pharmazie 321 (7), pp. 405-410.

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Abstract

PtCl2L (L = 1,2-bis(2-R-substituted)-4-methoxyphenyl)ethylenediamine) were prepd. from K2PtCl4 and L in the presence of tert-BuOH. Their effects on the human, hormone-independent MDA-MB 231 breast cancer cell line and on the lymphocytic leukemia P 388 of the mouse is compared with that of PtCl2L1 (L1 = 1,2-bis(2-R-substituted)-4-hydroxyphenyl)ethylenediamine). PtCl2L1 are more active on both ...

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Item Type:Article
Date:1988
Additional information (public):CAN 109:103615 78-7 Inorganic Chemicals and Reactions 15663-27-1; 105856-12-0; 105856-14-2; 105856-16-4; 105856-18-6; 105856-20-0; 105928-12-9 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antitumor activity of); 105855-88-7 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antitumor activity of racemic); 105856-10-8P; 105856-11-9P; 105856-13-1P; 105856-15-3P; 105856-17-5P; 105856-19-7P; 116075-59-3P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and proton NMR and antitumor activity of); 105928-13-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and proton NMR and antitumor activity of racemic); 10025-99-7 (Dipotassium tetrachloroplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with bis(methoxyphenyl)ethylenediamines)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1988:503615Other
Keywords:Neoplasm inhibitors (platinum complexes with bis(hydroxyphenyl)ethylenediamines or bis(methoxyphenyl)ethylenediamines) antitumor activity platinum methoxyphenylethylenediamine ethylenediamine methoxyphenyl platinum complex
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Petra Gürster
Deposited On:12 Nov 2010 08:15
Last Modified:12 Nov 2010 08:15
Item ID:17669
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