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Antitumor activity of o-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes and their methyl ethers

Karl, Johann and Schönenberger, Helmut (1988) Antitumor activity of o-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes and their methyl ethers. Archiv der Pharmazie 321 (7), pp. 405-410.

Full text not available from this repository.

Abstract

PtCl2L (L = 1,2-bis(2-R-substituted)-4-methoxyphenyl)ethylenediamine) were prepd. from K2PtCl4 and L in the presence of tert-BuOH. Their effects on the human, hormone-independent MDA-MB 231 breast cancer cell line and on the lymphocytic leukemia P 388 of the mouse is compared with that of PtCl2L1 (L1 = 1,2-bis(2-R-substituted)-4-hydroxyphenyl)ethylenediamine). PtCl2L1 are more active on both tumor models than PtCl2L but are less active than cisplatin.

Item Type:

Article

Additional information (public):

CAN 109:103615 78-7 Inorganic Chemicals and Reactions 15663-27-1; 105856-12-0; 105856-14-2; 105856-16-4; 105856-18-6; 105856-20-0; 105928-12-9 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antitumor activity of); 105855-88-7 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antitumor activity of racemic); 105856-10-8P; 105856-11-9P; 105856-13-1P; 105856-15-3P; 105856-17-5P; 105856-19-7P; 116075-59-3P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and proton NMR and antitumor activity of); 105928-13-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and proton NMR and antitumor activity of racemic); 10025-99-7 (Dipotassium tetrachloroplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with bis(methoxyphenyl)ethylenediamines)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger

Projects:

SFB 234

Identification Number:

Value	Type
1988:503615	Other

Keywords:

Neoplasm inhibitors (platinum complexes with bis(hydroxyphenyl)ethylenediamines or bis(methoxyphenyl)ethylenediamines) antitumor activity platinum methoxyphenylethylenediamine ethylenediamine methoxyphenyl platinum complex

Subjects:

500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Yes

Owner:

Petra Gürster

Deposited On:

12 Nov 2010 09:15