Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex

Abstract

In rats, the Pt complex I inhibited prostate and mammary gland hormone-dependent tumors, but had no effect on any of the hormone-independent tumors tested. The prostatic tumor-inhibiting activity of I was better than that of the related ligand without Pt. The endocrine effects of I on accessory sex organ wt. and testosterone levels were only slightly less than those of the potent estrogen diethylstilbestrol (DES). The estrogenic effect of I, however, was lower than that of DES. These effects partially contribute to the antitumor activity. I had no antiandrogenic effect and only low or no steroid hormone receptor affinities. I was accumulated by tumors, however.