Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.
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In rats, the Pt complex I inhibited prostate and mammary gland hormone-dependent tumors, but had no effect on any of the hormone-independent tumors tested. The prostatic tumor-inhibiting activity of I was better than that of the related ligand without Pt. The endocrine effects of I on accessory sex organ wt. and testosterone levels were only slightly less than those of the potent estrogen diethylstilbestrol (DES). The estrogenic effect of I, however, was lower than that of DES. These effects partially contribute to the antitumor activity. I had no antiandrogenic effect and only low or no steroid hormone receptor affinities. I was accumulated by tumors, however.
|Additional information (public):||CAN 110:376 1-6 Pharmacology 58-22-0 (Testosterone) Role: BIOL (Biological study) (endocrine-active platinum complex effect on, of blood, prostatic tumor inhibition in relation to); 117773-99-6 Role: BIOL (Biological study) (hormone-dependent prostate carcinoma inhibition by)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Neoplasm inhibitors (carcinoma, endocrine-active platinum complex as, against hormone-dependent mammary and prostate gland cells) Reproductive organ (male accessory, endocrine-active platinum complex effect on, prostatic tumor inhibition in relation to) Prostate gland (neoplasm, carcinoma, inhibition of hormone-dependent, by endocrine-active platinum complex) Mammary gland (neoplasm, carcinoma, hormone-dependent, inhibition of, by endocrine-active platinum complex) hormone dependent prostate tumor platinum complex endocrine active platinum complex prostate tumor mammary tumor endocrine active platinum complex|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 08:11|
|Last Modified:||12 Nov 2010 08:11|