Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.
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In rats, the Pt complex I inhibited prostate and mammary gland hormone-dependent tumors, but had no effect on any of the hormone-independent tumors tested. The prostatic tumor-inhibiting activity of I was better than that of the related ligand without Pt. The endocrine effects of I on accessory sex organ wt. and testosterone levels were only slightly less than those of the potent estrogen ...
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|Additional Information (public):||CAN 110:376 1-6 Pharmacology 58-22-0 (Testosterone) Role: BIOL (Biological study) (endocrine-active platinum complex effect on, of blood, prostatic tumor inhibition in relation to); 117773-99-6 Role: BIOL (Biological study) (hormone-dependent prostate carcinoma inhibition by)|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
|Keywords:||Neoplasm inhibitors (carcinoma, endocrine-active platinum complex as, against hormone-dependent mammary and prostate gland cells) Reproductive organ (male accessory, endocrine-active platinum complex effect on, prostatic tumor inhibition in relation to) Prostate gland (neoplasm, carcinoma, inhibition of hormone-dependent, by endocrine-active platinum complex) Mammary gland (neoplasm, carcinoma, hormone-dependent, inhibition of, by endocrine-active platinum complex) hormone dependent prostate tumor platinum complex endocrine active platinum complex prostate tumor mammary tumor endocrine active platinum complex|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||12 Nov 2010 08:11|
|Last Modified:||12 Nov 2010 08:11|