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Synthesis of platinum dichloride complexes of pyridylmethylamine ligands and their activity against hormone-dependent mammary carcinoma

Brunner, Henri und Dafinger, Willi und Schönenberger, Helmut (1989) Synthesis of platinum dichloride complexes of pyridylmethylamine ligands and their activity against hormone-dependent mammary carcinoma. Inorganica chimica acta 156 (2), S. 291-301.

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Zusammenfassung

Fifteen ligands of the pyridylmethylamine type and their PtCl2 complexes were prepd., characterized and subjected to a screening system for evaluation of a specific activity against the hormone-dependent mammary carcinoma. To test the estrogenic activity of the ligands, the relative binding affinity (RBA, in vitro) and the uterotrophic and antiuterotrophic activities (mouse uterine wt. test, in ...

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Dokumentenart:Artikel
Datum:1989
Zusätzliche Informationen (Öffentlich):CAN 111:16657 78-7 Inorganic Chemicals and Reactions 6505-37-9 (2,6-Dichloro-3-methoxybenzaldehyde); 19447-00-8 (2,6-Dimethyl-4-methoxybenzaldehyde); 53039-48-8; 61000-21-3 (2,6-Dimethyl-4-methoxybenzyl alcohol); 121020-64-2 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reactions of, in prepn. of pyridylmethylamine ligands); 100-70-9 (2-Cyanopyridine) Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reactions of, pyridylmethylamine ligands by); 10294-33-4 (Boron tribromide); 10294-34-5 (Boron trichloride) Role: RCT (Reactant), RACT (Reactant or reagent) (deprotection by, of methoxy derivs. of pyridylmethylamines); 121131-35-9P; 121131-36-0P; 121131-37-1P; 121131-38-2P; 121131-39-3P; 121131-42-8P; 121131-43-9P; 121131-44-0P; 121131-45-1P; 121131-46-2P; 121131-47-3P; 121131-48-4P; 121131-49-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and activity of racemic, against hormone-dependent mammary carcinoma); 121131-40-6P; 121131-41-7P Role: PRP (Properties), SPN (Synthetic preparation), PREP (Preparation) (prepn. and activity of, against hormone-dependent mammary carcinoma); 58088-48-5P; 121020-52-8P; 121020-53-9P; 121020-54-0P; 121020-55-1P; 121020-56-2P; 121020-57-3P; 121020-58-4P; 121020-59-5P; 121020-60-8P; 121020-61-9P; 121020-62-0P; 121020-63-1P; 121037-14-7P; 121037-15-8P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and deprotection of); 91-02-1P; 6305-18-6P; 27049-45-2P; 121020-34-6P; 121020-35-7P; 121020-36-8P; 121020-37-9P; 121020-38-0P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with hydroxylamine hydrochloride, pyridylmethylamine ligand by); 1826-28-4P; 2116-73-6P; 58088-15-6P; 121020-39-1P; 121020-40-4P; 121020-41-5P; 121020-42-6P; 121020-43-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of, by zinc, pyridylmethylamine ligand by); 121020-44-8P; 121020-45-9P; 121020-46-0P; 121020-47-1P; 121020-48-2P; 121020-49-3P; 121020-50-6P; 121037-13-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of, pyridylmethylamine deriv. by); 121020-19-7P; 121020-20-0P; 121020-21-1P; 121020-22-2P; 121020-23-3P; 121020-24-4P; 121020-25-5P; 121020-26-6P; 121020-27-7P; 121020-28-8P; 121020-29-9P; 121020-30-2P; 121020-31-3P; 121020-32-4P; 121020-33-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 2746-25-0; 61000-22-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with pyridyltrimethylsiloxyacetonitrile in prepn. of pyridylmethylamines); 71189-77-0 (2-Pyridyltrimethylsiloxyacetonitrile) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with benzyl bromides in prepn. of pyridylmethylamines); 5470-11-1 (Hydroxylamine hydrochloride) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with pyridyl ketones followed by redn. in prepn. of pyridylmethylamine ligands); 83-38-5; 123-11-5; 10025-99-7 (Dipotassium tetrachloroplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with pyridylmethylamines); 7440-66-6 (Zinc) Role: RCT (Reactant), RACT (Reactant or reagent) (redn. by, of pyridylmethyl oximes in prepn. of pyridylmethylamine derivs.); 16853-85-3 (Lithium aluminum hydride); 16940-66-2 (Sodium tetrahydroborate) Role: RCT (Reactant), RACT (Reactant or reagent) (redn. by, of pyridylmethylimines)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger
Projekte:SFB 234
Identifikationsnummer:
WertTyp
1989:416657Andere
Stichwörter / Keywords:Neoplasm inhibitors (lymphocytic leukemia, platinum complexes with pyridylmethylamines) Neoplasm inhibitors (mammary gland carcinoma, platinum complexes with pyridylmethylamines) cytotoxicity platinum pyridylmethylamine complex aminepyridylmethyl platinum complex
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:12 Nov 2010 08:09
Zuletzt geändert:12 Nov 2010 08:09
Dokumenten-ID:17672
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