Contact Imprint

Synthesis of platinum dichloride complexes of pyridylmethylamine ligands and their activity against hormone-dependent mammary carcinoma

Brunner, Henri and Dafinger, Willi and Schönenberger, Helmut (1989) Synthesis of platinum dichloride complexes of pyridylmethylamine ligands and their activity against hormone-dependent mammary carcinoma. Inorganica chimica acta 156 (2), pp. 291-301.

Full text not available from this repository.

Abstract

Fifteen ligands of the pyridylmethylamine type and their PtCl2 complexes were prepd., characterized and subjected to a screening system for evaluation of a specific activity against the hormone-dependent mammary carcinoma. To test the estrogenic activity of the ligands, the relative binding affinity (RBA, in vitro) and the uterotrophic and antiuterotrophic activities (mouse uterine wt. test, in vivo) were detd. To study the cytotoxic effects, the PtCl2 complexes were tested in vitro towards the hormone-independent human mammary carcinoma cell line MDA-MB 231 and in vivo towards the lymphocytic P388 leukemia. Finally, there was a comparative test of ligands and PtCl2 complexes in the hormone-independent MXT (3.2) Ovex mammary carcinoma and the hormone-dependent MXT M3.2 mammary carcinoma.

Item Type:Article
Additional information (public):CAN 111:16657 78-7 Inorganic Chemicals and Reactions 6505-37-9 (2,6-Dichloro-3-methoxybenzaldehyde); 19447-00-8 (2,6-Dimethyl-4-methoxybenzaldehyde); 53039-48-8; 61000-21-3 (2,6-Dimethyl-4-methoxybenzyl alcohol); 121020-64-2 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reactions of, in prepn. of pyridylmethylamine ligands); 100-70-9 (2-Cyanopyridine) Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reactions of, pyridylmethylamine ligands by); 10294-33-4 (Boron tribromide); 10294-34-5 (Boron trichloride) Role: RCT (Reactant), RACT (Reactant or reagent) (deprotection by, of methoxy derivs. of pyridylmethylamines); 121131-35-9P; 121131-36-0P; 121131-37-1P; 121131-38-2P; 121131-39-3P; 121131-42-8P; 121131-43-9P; 121131-44-0P; 121131-45-1P; 121131-46-2P; 121131-47-3P; 121131-48-4P; 121131-49-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and activity of racemic, against hormone-dependent mammary carcinoma); 121131-40-6P; 121131-41-7P Role: PRP (Properties), SPN (Synthetic preparation), PREP (Preparation) (prepn. and activity of, against hormone-dependent mammary carcinoma); 58088-48-5P; 121020-52-8P; 121020-53-9P; 121020-54-0P; 121020-55-1P; 121020-56-2P; 121020-57-3P; 121020-58-4P; 121020-59-5P; 121020-60-8P; 121020-61-9P; 121020-62-0P; 121020-63-1P; 121037-14-7P; 121037-15-8P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and deprotection of); 91-02-1P; 6305-18-6P; 27049-45-2P; 121020-34-6P; 121020-35-7P; 121020-36-8P; 121020-37-9P; 121020-38-0P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with hydroxylamine hydrochloride, pyridylmethylamine ligand by); 1826-28-4P; 2116-73-6P; 58088-15-6P; 121020-39-1P; 121020-40-4P; 121020-41-5P; 121020-42-6P; 121020-43-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of, by zinc, pyridylmethylamine ligand by); 121020-44-8P; 121020-45-9P; 121020-46-0P; 121020-47-1P; 121020-48-2P; 121020-49-3P; 121020-50-6P; 121037-13-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of, pyridylmethylamine deriv. by); 121020-19-7P; 121020-20-0P; 121020-21-1P; 121020-22-2P; 121020-23-3P; 121020-24-4P; 121020-25-5P; 121020-26-6P; 121020-27-7P; 121020-28-8P; 121020-29-9P; 121020-30-2P; 121020-31-3P; 121020-32-4P; 121020-33-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 2746-25-0; 61000-22-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with pyridyltrimethylsiloxyacetonitrile in prepn. of pyridylmethylamines); 71189-77-0 (2-Pyridyltrimethylsiloxyacetonitrile) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with benzyl bromides in prepn. of pyridylmethylamines); 5470-11-1 (Hydroxylamine hydrochloride) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with pyridyl ketones followed by redn. in prepn. of pyridylmethylamine ligands); 83-38-5; 123-11-5; 10025-99-7 (Dipotassium tetrachloroplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with pyridylmethylamines); 7440-66-6 (Zinc) Role: RCT (Reactant), RACT (Reactant or reagent) (redn. by, of pyridylmethyl oximes in prepn. of pyridylmethylamine derivs.); 16853-85-3 (Lithium aluminum hydride); 16940-66-2 (Sodium tetrahydroborate) Role: RCT (Reactant), RACT (Reactant or reagent) (redn. by, of pyridylmethylimines)
Institutions: Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1989:416657Other
Keywords:Neoplasm inhibitors (lymphocytic leukemia, platinum complexes with pyridylmethylamines) Neoplasm inhibitors (mammary gland carcinoma, platinum complexes with pyridylmethylamines) cytotoxicity platinum pyridylmethylamine complex aminepyridylmethyl platinum complex
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner:Petra Gürster
Deposited On:12 Nov 2010 09:09
Last Modified:12 Nov 2010 09:09
Item ID:17672
Export bibliographical data
Literature of the same author
plusin this repository
plusat BASE
plusat Google Scholar
plusat Scirus
Bookmark
Owner Only: item control page
University Library of Regensburg - 93042 Regensburg, Germany - University
Tel.: 0941 943-3990 (Information) - Contact Information - Imprint

The Publicationserver supports supports OAI 2.0 with a base URL of http://epub.uni-regensburg.de/cgi/oai2